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Volume 2 Issue 4, April 2017

Volume 2 Issue 4

Stopping RSV in its tracks

Crystal structures of two potent RSV antibodies in complex with the RSV fusion protein determine the molecular basis for neutralization of the virus, including a new antigenic site and the basis for cross-reactivity with human metapneumovirus.

see Mousa, J. J. et al. 2, 16271 (2017) and Wen, X. et al. 2, 16272 (2017)

Image: James Crowe and Jarrod Mousa, Cover Design: Samantha Whitham

Editorial

  • Editorial |

    As anti-vaccination movements gain momentum in some regions, World Immunization Week 2017 reminds us that vaccines work and are safe, and that ideological positions contrary to this truth ignore the weight of scientific evidence and deny a long history of lives being saved, endangering many more.

Comment & Opinion

  • Q&A |

    We asked Jill Banfield, a mineralogist-turned-microbiologist, how she became interested in microbial communities, what she thinks about field work, how she manages a multidisciplinary team, and where microbiome studies are headed next.

    • Cláudio Nunes-Alves

News & Views

  • News & Views |

    Rodent malaria parasites establish chronic infections through the sequential expression of subsets of variant antigen-encoding genes, a process that surprisingly appears to be independent of adaptive immunity.

    • Kirk W. Deitsch
  • News & Views |

    Attaching and effacing enteropathogenic Escherichia coli causes gastrointestinal inflammation and diarrhoea. In this issue of Nature Microbiology, Pearson and colleagues find that this pathology involves bacterial cleavage of a class of host cell death signal adaptors that encode a unique protein interaction motif called the RHIM.

    • Thiago DeSouza-Vieira
    • Francis Ka-Ming Chan

Reviews

  • Perspective |

    Environmental geomicrobial studies offer insights into the structure and function of the built environment microbiome.

    • Geoffrey Michael Gadd
  • Perspective |

    Amalgamation of population genetic theory and models of horizontal gene transfer suggest that pangenomes in prokaryotes result from adaptive, not neutral, evolution.

    • James O. McInerney
    • Alan McNally
    • Mary J. O'Connell

Research

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