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Almost twenty years after it was first linked to control of Mycobacterium tuberculosis in macrophages, autophagy retakes centre stage, as shown in murine models and human cells.
Bladder epithelial cells exposed to uropathogenic Escherichia coli infection have long-lasting epigenetic modifications linked with inflammation that influence host susceptibility to subsequent infections.
Phage-encoded endolysins released from neighbouring infected bacterial cells can confer a temporary resistance to phage infection by mediating the reversible loss of the cell wall.
Mycobacterium abscessus requires high levels of biotin biosynthesis during infection, because this vitamin enables key adaptations to the alkaline lung airway environment through fatty acid remodelling that increases fluidity of the cell envelope.
‘Candidatus Methanoperedens nitroreducens’, an anaerobic methanotrophic archaeon, sectors itself into two morphologically and functionally distinct populations that enable adaptation and cross-species interactions in a dynamic bioreactor ecosystem.
New World arenaviruses are pathogens capable of zoonotic infections that cause viral haemorrhagic fevers, which are frequently lethal in humans. However, a recombinant live-attenuated pentavalent vaccine shows promising efficacy against infection.