News & Views in 2022

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  • The gut microorganism Clostridium sporogenes can utilize amino-acid pairs to generate energy, and the resulting metabolites circulate in host plasma.

    • Alexander S. Little
    • Samuel H. Light
    News & Views
  • Dysbiosis of the gut microbiome is associated with increased susceptibility to recurrent urinary tract infection, defining a gut–bladder axis.

    • Mark A. Schembri
    • Nguyen Thi Khanh Nhu
    • Minh-Duy Phan
    News & Views
  • Bacterial taxa within the murine gut microbiota affect susceptibility to the widely used dextran sodium sulfate model of colitis.

    • Andrew J. Macpherson
    • Bahtiyar Yilmaz
    News & Views
  • “Everything is everywhere, but, the environment selects” — a hypothesis formulated by Lourens Baas Becking in 1934 — is used to frame research that analyses the sharing of Escherichia coli strains across humans, livestock and wildlife animals.

    • Willem van Schaik
    News & Views
  • Metabolic changes in auxotrophs enrich the microbial community exometabolome and increase drug resistance.

    • Kevin R. Stindt
    • Megan N. McClean
    News & Views
  • Contractile injection systems are nanomachines used by bacteria to puncture target cell membranes, thereby mediating bacterial competition and infection of eukaryotic cells. Two studies shed light on the structural diversity of these molecular spearguns using advanced multiscale imaging techniques.

    • Ricardo D. Righetto
    • Benjamin D. Engel
    News & Views
  • A potential new therapeutic approach that targets the unique nutrient requirements of Lactobacillus iners to improve bacterial vaginosis treatment outcomes is described.

    • Lindi Masson
    • Andrea G. Abrahams
    • Monalisa T. Manhanzva
    News & Views
  • Infection by Mycobacterium tuberculosis (Mtb) induces remodelling of the host-cell transcriptome, which is mediated by epigenetic mechanisms. Histone acetylation of KCNJ15 stimulates transcription and the activation of genes implicated in apoptosis to promote Mtb clearance.

    • Melanie A. Carless
    • Larry S. Schlesinger
    News & Views
  • Homeodomain protein 1 (HDP1), a DNA-binding protein unrelated to AP2 transcription factors, has been identified as a regulator of gametocyte maturation in Plasmodium falciparum.

    • Kim C. Williamson
    News & Views
  • A combination of highly accurate long-read sequencing and genome contact maps has been used to produce hundreds of lineage-resolved metagenome-assembled genomes from a complex microbial community isolated from a sheep fecal sample.

    • Taylor E. Reiter
    • C. Titus Brown
    News & Views