News & Comment

To those who seek transcriptomic information at high resolution, scale and throughput, single-cell RNA sequencing brings the data. Scientists share tips and future plans as they reflect on the method’s rise to stardom.

Organoids are an emerging way to model the fraught complexity of tumors.

Collaborations between researchers and companies can progress swimmingly and teams quickly validate findings and mature methods. All too often, things can’t advance and the ‘Valley of Death’ looms. New ways to collaborate, underpinned by computational muscle, can help.

Human cells contain crowds of protein variants, but, especially in a time of funding challenges, chasing these proteoforms takes dogged persistence.

As money pours into aging research, the field can combine its many methods to home in on what underpins aging. Approaches differ, but researchers share the desire to not overpromise quick-fix anti-aging methods.