News & Comment

Aberrations hinder clear imaging, but an array of options help to correct much distortion.

A wealth of spatial techniques capture the 'where' of gene expression.

Trial, error and the art of optimizing 'molecular rulers' that sense molecules or interactions.

X-ray beams at 27,000 pulses per second promise high-resolution views of macromolecules.

Coaxing ancient DNA to reveal its history delivers surprises and even improves ways of working with badly damaged present-day DNA.

Carbohydrates are tough molecules to study, but glycoscientists are developing and democratizing the needed tools.

3D human cell cultures are changing the way scientists model organ development and function—but they have their own set of complications.

PCR duplicates—sequencing reads from the same original genomic fragment—can cause headaches. But there are remedies.

Many possibilities for parsing cancer emerge when labs combine gene editing and screens. And RNAi retains its spot in the menu of options.

The tools that clock a cell's everyday affairs reveal plenty that's out of the ordinary.

Efforts to pare away cellular genomes are yielding streamlined biosynthetic factories and deeper insights into the core processes of biology.