News & Comment

Moving and sorting cells with sound are a few of the possible applications for this no-contact technique.

Tissue samples scatter light and shut out a deeper gaze. Tissue-clearing agents have changed that, but scientists must consider optimizing the optics when using these methods.

Electrodes and electrode arrays to record from neurons come in an increasing number of shapes and sizes, and engineers are continuously adding capabilities.

Efficiently cutting a target sequence to effect a desired change in the genome is one gene-editing task. Knowing where else in the genome a tool might have made its mark is quite another.

X-ray free-electron lasers (XFELs) offer opportunities beyond classic X-ray crystallography, particularly for proteins that are difficult to crystallize.

Managing, sharing and controlling the quality of plasmids can be simple. But many techniques to disseminate them do not scale, which leads nonprofits and companies to explore new options.

Peering into live cells and tissues with genetically encoded near-infrared probes requires addressing a number of hurdles.

Cell lines are better. Mice are better. Beyond disagreement about model systems and even passionate discord at times, new strategies help to explore the middle ground so models might better approximate human biology.

Some researchers run and hide from the task of authenticating cell lines. A few simple steps save time and money.

Tumors impart hints at what drives their progression. Parsing those signals takes old and new approaches.

Careful strategizing helps make PCR sensitive enough for the most challenging experiments.

Identifying functional regions in genomes takes scientists beyond protein-coding regions and into stretches formerly known as genomic deserts.