News & Comment

Apparently redundant codons may not be redundant after all.

A noise-reduction algorithm decreases the amount of light needed for live-cell fluorescence microscopy by orders of magnitude.

Using real-time labeling with fluorescent ligands, researchers track thousands of endogenous proteins at the surface of living cells.

A split protease under small-molecule control selectively activates the executioner caspases involved in apoptosis.

A haplotype map based on 11 global populations will provide a better understanding of human genome architecture.

A nanoscale field-effect transistor with a three-dimensional probe-presentation design can record intracellular potentials from single cells.

Harmonic-generation microscopy takes the stage to provide biologists with a useful adjunct to fluorescence imaging.

A trackable multiplex recombineering method in Escherichia coli allows for the identification of genes that affect a selectable trait.

Engineered kinases remain off in cells until turned on by small molecules.

Single DNA molecules stretched in a nanochannel display melting patterns characteristic of their sequence.

The strength of selection that acts on a growing population of cells and the presence of a stochastic switching mechanism may be inferred from lineage data.

Application of single-molecule methods to assay genome-wide mRNA and protein levels in single bacteria provides a systems-level view of their relationship.

Researchers designed an enzyme to carry out the Diels-Alder reaction, an activity not found in nature.

Researchers solve a high-resolution structure of a seven-helix transmembrane protein using nuclear magnetic resonance (NMR) spectroscopy.

Analysis of RNA sequencing data points to fewer intergenic transcripts than assumed. Isolating them via chromatin association may enrich for functional noncoding transcripts.

To site-specifically label proteins in living cells, researchers mutate an enzyme to recognize a small fluorophore and catalyze its attachment to a small peptide tag.

Nanotube arrays, imprinted with proteins, can be used as biosensors.