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  • Dramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are currently limited by the fact that they predict only a single structure, instead of a structural distribution, and that this realization is crucial for the next generation of structure prediction algorithms.

    • Thomas J. Lane
    Comment
  • Mechanoimmunology methods help dissect the mechanical forces within the immune system.

    • Madhura Mukhopadhyay
    Method to Watch
  • CRISPR systems can be leveraged to direct recombinases to integrate gene-sized DNA sequences.

    • Lei Tang
    Method to Watch
  • Strategies to overcome poor reproducibility in MRI studies are needed.

    • Nina Vogt
    Method to Watch
  • In vitro models and single-cell atlases help uncover the mysteries of human embryogenesis.

    • Madhura Mukhopadhyay
    Method to Watch
  • Computational approaches are pushing the limits of unknown metabolite annotation.

    • Arunima Singh
    Method to Watch
  • Advances in fluorescence microscopy and spectroscopy show their promise for applications that complement in situ structural biology methods like cryoelectron tomography.

    • Rita Strack
    Method to Watch
  • The combination of microscopy, targeted illumination and single-cell sequencing is driving applications from direct evolution to spatial omics.

    • Rita Strack
    Method to Watch
  • Data integration methods weave genomics data into holistic pictures of biological systems.

    • Lin Tang
    Method to Watch
  • Many scientists are active on social media, especially Twitter. The social media world is changing, but these researchers want to stay socially connected.

    • Vivien Marx
    This Month
  • Planaria are a group of worms within the phylum Platyhelminthes (flatworms). Many species, including Schmidtea mediterranea, have the ability to regenerate their body from small pieces of tissue and are easy to keep in the laboratory, which makes them a prime model system for studying whole-body regeneration.

    • Leonard Drees
    • Jochen C. Rink
    This Month
  • Spatially resolved and single-cell transcriptomics provide insights into tumor heterogeneity and tumor–microbiome interactions.

    • Nina Vogt
    Research Highlight
  • Long-read sequencing has become a widely employed technology that enables a comprehensive view of RNA transcripts. Here, we discuss the importance of long-read sequencing in interpreting the variables along RNA molecules, such as polyadenylation sites, transcription start sites, splice sites and other RNA modifications. In addition, we highlight the history of short-read and long-read technologies and their advantages and disadvantages, as well as future directions in the field.

    • Careen Foord
    • Justine Hsu
    • Hagen U. Tilgner
    Comment
  • To large-scale projects and individual labs, long-read sequencing has delivered new vistas and long wish lists for this technology’s future.

    • Vivien Marx
    News Feature
  • The year 2022 will be remembered as the turning point for accurate long-read sequencing, which now establishes the gold standard for speed and accuracy at competitive costs. We discuss the key bioinformatics techniques needed to power long reads across application areas and close with our vision for long-read sequencing over the coming years.

    • Sam Kovaka
    • Shujun Ou
    • Michael C. Schatz
    Comment