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PdCO is a switchable optogenetic tool for inhibiting synaptic transmission in neuronal terminals in vivo, as demonstrated in a variety of contexts mainly in the mouse.
An experimental method to study how cells sense and react to external mechanical forces combines controlled mechanical stimulation using nanopipettes with fluorescence imaging of membrane tension. This approach facilitates the study of mechanosensitive ion channels and the propagation of cell membrane tension.
FluidFM-based force-controlled nanopipettes enable control of mechanical stimuli for the investigation of Piezo1-induced mechanosensation in cell membranes.
Dimension reduction helps to visualize high-dimensional datasets. These tools should be used thoughtfully and with tuned parameters. Sometimes, these methods take a second thought.
Sometimes their queer identity is one that people set apart from their science identity. Others find unique ways to integrate multiple facets of their identity.
Using a dependency-aware deep generative framework, spaVAE efficiently models spatially resolved transcriptomics data and advances diverse analysis tasks. Following similar strategies, spaPeakVAE and spaMultiVAE enable spatial ATAC-seq data and spatial multi-omics data modeling and analysis, respectively.
Spatial transcriptomics and mRNA splicing measurements encode rich spatiotemporal information for cell states and their transitions. We present a multiscale dynamical system method for reconstructing cell-state-specific dynamics and spatial state transitions. This theory-based approach reconciles short-timescale local tensor streamlines between cells with long-timescale transition paths that connect cell attractors.
Pebblescout navigates vast, rapidly growing nucleotide content in resources by providing indexing and search capabilities. We used Pebblescout to index a metagenomic subset of Sequence Read Archive and seven other resources into databases spanning over 3.7 petabases and searchable interactively at a pilot website using queries as short as 42 bases.
The Consortium for Top-Down Proteomics conducted a study to develop and test protocols for native mass spectrometry combined with top-down fragmentation of proteins and protein complexes across eleven instruments in nine laboratories. They report the summary of the outcomes and their recommendations in this Analysis.
OpenFold is a trainable open-source implementation of AlphaFold2. It is fast and memory efficient, and the code and training data are available under a permissive license.