News & Views in 2018

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  • A recent approach for single-cell RNA-sequencing data uses Bayesian deep learning to correct technical artifacts and enable accurate and multifaceted downstream analyses.

    • Gregory P. Way
    • Casey S. Greene
    News & Views
  • A type of neural network first described in 2015 can be trained to translate between images of the same field of view acquired by different modalities. Trained networks can use information inherent in grayscale images of cells to predict fluorescent signals.

    • Roger Brent
    • Laura Boucheron
    News & Views
  • A new article by Pandarinath et al. describes an artificial neural network model that captures some key aspects of the activity of populations of neurons in the primary motor cortex.

    • Aaron P. Batista
    • James J. DiCarlo
    News & Views
  • A new detector built for X-ray free-electron lasers provides unprecedented speed and accuracy for macromolecular crystallography at synchrotron radiation facilities—and finally allows crystallographers to harness the full capabilities of those sources.

    • Henry N. Chapman
    News & Views
  • Quanti.us is a platform that allows large-scale manual image annotation by a distributed workforce through Amazon’s Mechanical Turk crowdsourcing marketplace.

    • Martin L. Jones
    • Helen Spiers
    News & Views
  • Overexpression of mouse thymic-stromal-cell-derived lymphopoietin in immune-compromised mice that harbor a reconstituted human immune system rescues lymph node formation and enhances adaptive immune responses.

    • Alexandre P. A. Theocharides
    • Markus G. Manz
    News & Views
  • Two methods for controlling protein activities with small molecules provide a general solution to a long-standing challenge in mammalian synthetic biology.

    • Bryan C. Dickinson
    News & Views
  • An interpretable, deep neural network produces mechanistic hypotheses on how genetic interactions contribute to whole-cell phenotypes.

    • Kristin Branson
    News & Views