Editorials in 2008

With its tremendous potential for understanding cellular biology now poised to become a reality, super-resolution fluorescence microscopy is our choice for Method of the Year.

Sequencing technology is now advanced enough to decode individual human genomes. Will it prove to be better than existing methods for discovering the genetic basis of human phenotypic variation?

The fourth anniversary of Nature Methods' arrival on the publishing scene and a change in leadership offer an opportunity for reflection and editorial fine-tuning.

A feasibility study for the systematic generation of affinity reagents to human proteins provides an opportunity to test the merits of recombinant affinity reagents.

You can now nominate candidates and vote online to help select the Method of the Year 2008.

A constant influx of new methods keeps research on microRNA biology fast-paced and can provide divergent vantage points.

The use of organized competition to evaluate algorithm performance would be very beneficial for small communities, not just large ones.

With access to high-throughput technologies, researchers struggle to store their raw data. Many just give up.

Biologists are increasingly interested in single-molecule approaches. In this issue, a Focus provides a biologist's guide to this relatively new field, and two papers present advances in nanoscale visualization.

Presenting at a conference is a unique opportunity to broadly communicate your work. Here are ten suggestions to make the most of it.

Experimental comparisons of methods, technology platforms or reagents are time-consuming and expensive, but hugely beneficial. Enter the Analysis article format.

Starting this month, Nature Methods strongly recommends deposition of proteomics data to public repositories before manuscript submission.

Structural genomics efforts have spurred the continuing development of new methods and technologies, benefiting a broad community.

There are events of the year, persons of the year, images of the year.... We could not resist: why not a Method of the Year?