Volume 43 Issue 4, April 2011

Volume 43 Issue 4

Cover art: Updraft by Mitch Lyons from eo art lab http://eoartlab.com

Editorial

  • Editorial |

    The first Human Variome microattribution review shows that data citation and publication credit can work as incentives for systematic curation of gene variant and phenotype data. Analysis of the formal assertions in both databases and journal articles argues for better separation of data structures from narrative so that they can better support one another to communicate meaning.

Commentary

  • Commentary |

    • Barend Mons
    • , Herman van Haagen
    • , Christine Chichester
    • , Peter-Bram 't Hoen
    • , Johan T den Dunnen
    • , Gertjan van Ommen
    • , Erik van Mulligen
    • , Bharat Singh
    • , Rob Hooft
    • , Marco Roos
    • , Joel Hammond
    • , Bruce Kiesel
    • , Belinda Giardine
    • , Jan Velterop
    • , Paul Groth
    •  & Erik Schultes

Book Review

News and Views

  • News & Views |

    A new study successfully applies complementary whole-genome sequencing and imputation approaches to establish robust disease associations in an isolated population. This strategy is poised to help elucidate the role of variants at the low end of the allele frequency spectrum in the genetic architecture of complex traits.

    • Eleftheria Zeggini
  • News & Views |

    MicroRNAs (miRNAs) regulate expression of more than one half of the genes in the human genome. A study now reports a new method for selectively silencing whole families of miRNAs, thus providing a new paradigm for disease therapy.

    • John J Rossi
  • News & Views |

    New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.

    • Mrinal Y Shah
    •  & Jonathan D Licht

Research Highlights

Analysis

  • Analysis | | open

    George Patrinos and colleagues report the first implementation of the microattribution approach to systematically document genetic variation associated with a disease, applied here to hemoglobinopathies and thalassemias. They developed a series of connected locus-specific databases that document genotype and phenotype information for genetic variation in 37 globin and erythroid protein genes in individuals with globin disorders, with reciprocal attribution to data contributors.

    • Belinda Giardine
    • , Joseph Borg
    • , Douglas R Higgs
    • , Kenneth R Peterson
    • , Sjaak Philipsen
    • , Donna Maglott
    • , Belinda K Singleton
    • , David J Anstee
    • , A Nazli Basak
    • , Barnaby Clark
    • , Flavia C Costa
    • , Paula Faustino
    • , Halyna Fedosyuk
    • , Alex E Felice
    • , Alain Francina
    • , Renzo Galanello
    • , Monica V E Gallivan
    • , Marianthi Georgitsi
    • , Richard J Gibbons
    • , Piero C Giordano
    • , Cornelis L Harteveld
    • , James D Hoyer
    • , Martin Jarvis
    • , Philippe Joly
    • , Emmanuel Kanavakis
    • , Panagoula Kollia
    • , Stephan Menzel
    • , Webb Miller
    • , Kamran Moradkhani
    • , John Old
    • , Adamantia Papachatzopoulou
    • , Manoussos N Papadakis
    • , Petros Papadopoulos
    • , Sonja Pavlovic
    • , Lucia Perseu
    • , Milena Radmilovic
    • , Cathy Riemer
    • , Stefania Satta
    • , Iris Schrijver
    • , Maja Stojiljkovic
    • , Swee Lay Thein
    • , Jan Traeger-Synodinos
    • , Ray Tully
    • , Takahito Wada
    • , John S Waye
    • , Claudia Wiemann
    • , Branka Zukic
    • , David H K Chui
    • , Henri Wajcman
    • , Ross C Hardison
    •  & George P Patrinos

Brief Communications

  • Brief Communication |

    Richard Trembath and colleagues show that mutations in NOTCH2 cause Hajdu-Cheney syndrome, a multisystem disorder marked by severe and progressive bone loss. The mutations are predicted to result in elevated NOTCH2 signaling.

    • Michael A Simpson
    • , Melita D Irving
    • , Esra Asilmaz
    • , Mary J Gray
    • , Dimitra Dafou
    • , Frances V Elmslie
    • , Sahar Mansour
    • , Sue E Holder
    • , Caroline E Brain
    • , Barbara K Burton
    • , Katherine H Kim
    • , Richard M Pauli
    • , Salim Aftimos
    • , Helen Stewart
    • , Chong Ae Kim
    • , Muriel Holder-Espinasse
    • , Stephen P Robertson
    • , William M Drake
    •  & Richard C Trembath
  • Brief Communication |

    Cédric Le Caignec and colleagues show that truncating mutations in the last exon of NOTCH2 cause Hajdu-Cheney syndrome, a rare disorder marked by facial anomalies, osteoporosis and multiple organ defects. The mutations are predicted to result in an increase in NOTCH2 signaling.

    • Bertrand Isidor
    • , Pierre Lindenbaum
    • , Olivier Pichon
    • , Stéphane Bézieau
    • , Christian Dina
    • , Sébastien Jacquemont
    • , Dominique Martin-Coignard
    • , Christel Thauvin-Robinet
    • , Martine Le Merrer
    • , Jean-Louis Mandel
    • , Albert David
    • , Laurence Faivre
    • , Valérie Cormier-Daire
    • , Richard Redon
    •  & Cédric Le Caignec

Articles

  • Article |

    Zhu Chen, Sai-Juan Chen and colleagues report exome sequencing of acute monocytic leukemia, a subtype of acute myeloid leukemia. They identified somatic mutations of DNMT3A, which encodes a DNA methyltransferase, in 20% of cases.

    • Xiao-Jing Yan
    • , Jie Xu
    • , Zhao-Hui Gu
    • , Chun-Ming Pan
    • , Gang Lu
    • , Yang Shen
    • , Jing-Yi Shi
    • , Yong-Mei Zhu
    • , Lin Tang
    • , Xiao-Wei Zhang
    • , Wen-Xue Liang
    • , Jian-Qing Mi
    • , Huai-Dong Song
    • , Ke-Qin Li
    • , Zhu Chen
    •  & Sai-Juan Chen
  • Article |

    Hilma Holm et al. report a rare missense variant MYH6 that is associated with a high risk of sick sinus syndrome in Icelanders. This heart condition is found most often in elderly people and is the most frequent reason a heart pacemaker is implanted.

    • Hilma Holm
    • , Daniel F Gudbjartsson
    • , Patrick Sulem
    • , Gisli Masson
    • , Hafdis Th Helgadottir
    • , Carlo Zanon
    • , Olafur Th Magnusson
    • , Agnar Helgason
    • , Jona Saemundsdottir
    • , Arnaldur Gylfason
    • , Hrafnhildur Stefansdottir
    • , Solveig Gretarsdottir
    • , Stefan E Matthiasson
    • , Gu∂mundur Thorgeirsson
    • , Aslaug Jonasdottir
    • , Asgeir Sigurdsson
    • , Hreinn Stefansson
    • , Thomas Werge
    • , Thorunn Rafnar
    • , Lambertus A Kiemeney
    • , Babar Parvez
    • , Raafia Muhammad
    • , Dan M Roden
    • , Dawood Darbar
    • , Gudmar Thorleifsson
    • , G Bragi Walters
    • , Augustine Kong
    • , Unnur Thorsteinsdottir
    • , David O Arnar
    •  & Kari Stefansson
  • Article |

    Ali Gharavi, Rick Lifton and colleagues report a genome-wide association study for IgA nephropathy, a major cause of kidney failure. They identify five susceptibility loci.

    • Ali G Gharavi
    • , Krzysztof Kiryluk
    • , Murim Choi
    • , Yifu Li
    • , Ping Hou
    • , Jingyuan Xie
    • , Simone Sanna-Cherchi
    • , Clara J Men
    • , Bruce A Julian
    • , Robert J Wyatt
    • , Jan Novak
    • , John C He
    • , Haiyan Wang
    • , Jicheng Lv
    • , Li Zhu
    • , Weiming Wang
    • , Zhaohui Wang
    • , Kasuhito Yasuno
    • , Murat Gunel
    • , Shrikant Mane
    • , Sheila Umlauf
    • , Irina Tikhonova
    • , Isabel Beerman
    • , Silvana Savoldi
    • , Riccardo Magistroni
    • , Gian Marco Ghiggeri
    • , Monica Bodria
    • , Francesca Lugani
    • , Pietro Ravani
    • , Claudio Ponticelli
    • , Landino Allegri
    • , Giuliano Boscutti
    • , Giovanni Frasca
    • , Alessandro Amore
    • , Licia Peruzzi
    • , Rosanna Coppo
    • , Claudia Izzi
    • , Battista Fabio Viola
    • , Elisabetta Prati
    • , Maurizio Salvadori
    • , Renzo Mignani
    • , Loreto Gesualdo
    • , Francesca Bertinetto
    • , Paola Mesiano
    • , Antonio Amoroso
    • , Francesco Scolari
    • , Nan Chen
    • , Hong Zhang
    •  & Richard P Lifton

Letters

  • Letter |

    Carl Anderson and colleagues report a genome-wide association study identifying 13 new susceptibility loci for primary biliary cirrhosis, a chronic autoimmune liver disease.

    • George F Mells
    • , James A B Floyd
    • , Katherine I Morley
    • , Heather J Cordell
    • , Christopher S Franklin
    • , So-Youn Shin
    • , Michael A Heneghan
    • , James M Neuberger
    • , Peter T Donaldson
    • , Darren B Day
    • , Samantha J Ducker
    • , Agnes W Muriithi
    • , Elizabeth F Wheater
    • , Christopher J Hammond
    • , Muhammad F Dawwas
    • , The UK PBC Consortium
    • , The Wellcome Trust Case Control Consortium 3
    • , David E Jones
    • , Leena Peltonen
    • , Graeme J Alexander
    • , Richard N Sandford
    •  & Carl A Anderson
  • Letter |

    Heribert Schunkert and colleagues report a meta-analysis of 14 genome-wide association studies of coronary disease (CAD) followed by replication in additional cohorts. They confirm 10 previously associated loci and identify 13 loci newly associated with CAD.

    • Heribert Schunkert
    • , Inke R König
    • , Sekar Kathiresan
    • , Muredach P Reilly
    • , Themistocles L Assimes
    • , Hilma Holm
    • , Michael Preuss
    • , Alexandre F R Stewart
    • , Maja Barbalic
    • , Christian Gieger
    • , Devin Absher
    • , Zouhair Aherrahrou
    • , Hooman Allayee
    • , David Altshuler
    • , Sonia S Anand
    • , Karl Andersen
    • , Jeffrey L Anderson
    • , Diego Ardissino
    • , Stephen G Ball
    • , Anthony J Balmforth
    • , Timothy A Barnes
    • , Diane M Becker
    • , Lewis C Becker
    • , Klaus Berger
    • , Joshua C Bis
    • , S Matthijs Boekholdt
    • , Eric Boerwinkle
    • , Peter S Braund
    • , Morris J Brown
    • , Mary Susan Burnett
    • , Ian Buysschaert
    • , Cardiogenics
    • , John F Carlquist
    • , Li Chen
    • , Sven Cichon
    • , Veryan Codd
    • , Robert W Davies
    • , George Dedoussis
    • , Abbas Dehghan
    • , Serkalem Demissie
    • , Joseph M Devaney
    • , Patrick Diemert
    • , Ron Do
    • , Angela Doering
    • , Sandra Eifert
    • , Nour Eddine El Mokhtari
    • , Stephen G Ellis
    • , Roberto Elosua
    • , James C Engert
    • , Stephen E Epstein
    • , Ulf de Faire
    • , Marcus Fischer
    • , Aaron R Folsom
    • , Jennifer Freyer
    • , Bruna Gigante
    • , Domenico Girelli
    • , Solveig Gretarsdottir
    • , Vilmundur Gudnason
    • , Jeffrey R Gulcher
    • , Eran Halperin
    • , Naomi Hammond
    • , Stanley L Hazen
    • , Albert Hofman
    • , Benjamin D Horne
    • , Thomas Illig
    • , Carlos Iribarren
    • , Gregory T Jones
    • , J Wouter Jukema
    • , Michael A Kaiser
    • , Lee M Kaplan
    • , John J P Kastelein
    • , Kay-Tee Khaw
    • , Joshua W Knowles
    • , Genovefa Kolovou
    • , Augustine Kong
    • , Reijo Laaksonen
    • , Diether Lambrechts
    • , Karin Leander
    • , Guillaume Lettre
    • , Mingyao Li
    • , Wolfgang Lieb
    • , Christina Loley
    • , Andrew J Lotery
    • , Pier M Mannucci
    • , Seraya Maouche
    • , Nicola Martinelli
    • , Pascal P McKeown
    • , Christa Meisinger
    • , Thomas Meitinger
    • , Olle Melander
    • , Pier Angelica Merlini
    • , Vincent Mooser
    • , Thomas Morgan
    • , Thomas W Mühleisen
    • , Joseph B Muhlestein
    • , Thomas Münzel
    • , Kiran Musunuru
    • , Janja Nahrstaedt
    • , Christopher P Nelson
    • , Markus M Nöthen
    • , Oliviero Olivieri
    • , Riyaz S Patel
    • , Chris C Patterson
    • , Annette Peters
    • , Flora Peyvandi
    • , Liming Qu
    • , Arshed A Quyyumi
    • , Daniel J Rader
    • , Loukianos S Rallidis
    • , Catherine Rice
    • , Frits R Rosendaal
    • , Diana Rubin
    • , Veikko Salomaa
    • , M Lourdes Sampietro
    • , Manj S Sandhu
    • , Eric Schadt
    • , Arne Schäfer
    • , Arne Schillert
    • , Stefan Schreiber
    • , Jürgen Schrezenmeir
    • , Stephen M Schwartz
    • , David S Siscovick
    • , Mohan Sivananthan
    • , Suthesh Sivapalaratnam
    • , Albert Smith
    • , Tamara B Smith
    • , Jaapjan D Snoep
    • , Nicole Soranzo
    • , John A Spertus
    • , Klaus Stark
    • , Kathy Stirrups
    • , Monika Stoll
    • , W H Wilson Tang
    • , Stephanie Tennstedt
    • , Gudmundur Thorgeirsson
    • , Gudmar Thorleifsson
    • , Maciej Tomaszewski
    • , Andre G Uitterlinden
    • , Andre M van Rij
    • , Benjamin F Voight
    • , Nick J Wareham
    • , George A Wells
    • , H-Erich Wichmann
    • , Philipp S Wild
    • , Christina Willenborg
    • , Jaqueline C M Witteman
    • , Benjamin J Wright
    • , Shu Ye
    • , Tanja Zeller
    • , Andreas Ziegler
    • , Francois Cambien
    • , Alison H Goodall
    • , L Adrienne Cupples
    • , Thomas Quertermous
    • , Winfried März
    • , Christian Hengstenberg
    • , Stefan Blankenberg
    • , Willem H Ouwehand
    • , Alistair S Hall
    • , Panos Deloukas
    • , John R Thompson
    • , Kari Stefansson
    • , Robert Roberts
    • , Unnur Thorsteinsdottir
    • , Christopher J O'Donnell
    • , Ruth McPherson
    • , Jeanette Erdmann
    • , the CARDIoGRAM Consortium
    •  & Nilesh J Samani
  • Letter |

    Qing Wang and colleagues report a genome-wide association study for coronary artery disease (CAD) in a Chinese Han population. They identify a locus on chromosome 6p24.1 newly associated with CAD.

    • Fan Wang
    • , Cheng-Qi Xu
    • , Qing He
    • , Jian-Ping Cai
    • , Xiu-Chun Li
    • , Dan Wang
    • , Xin Xiong
    • , Yu-Hua Liao
    • , Qiu-Tang Zeng
    • , Yan-Zong Yang
    • , Xiang Cheng
    • , Cong Li
    • , Rong Yang
    • , Chu-Chu Wang
    • , Gang Wu
    • , Qiu-Lun Lu
    • , Ying Bai
    • , Yu-Feng Huang
    • , Dan Yin
    • , Qing Yang
    • , Xiao-Jing Wang
    • , Da-Peng Dai
    • , Rong-Feng Zhang
    • , Jing Wan
    • , Jiang-Hua Ren
    • , Si-Si Li
    • , Yuan-Yuan Zhao
    • , Fen-Fen Fu
    • , Yuan Huang
    • , Qing-Xian Li
    • , Sheng-Wei Shi
    • , Nan Lin
    • , Zhen-Wei Pan
    • , Yue Li
    • , Bo Yu
    • , Yan-Xia Wu
    • , Yu-He Ke
    • , Jian Lei
    • , Nan Wang
    • , Chun-Yan Luo
    • , Li-Ying Ji
    • , Lian-Jun Gao
    • , Lei Li
    • , Hui Liu
    • , Er-Wen Huang
    • , Jin Cui
    • , Na Jia
    • , Xiang Ren
    • , Hui Li
    • , Tie Ke
    • , Xian-Qin Zhang
    • , Jing-Yu Liu
    • , Mu-Gen Liu
    • , Hao Xia
    • , Bo Yang
    • , Li-Song Shi
    • , Yun-Long Xia
    • , Xin Tu
    •  & Qing K Wang
  • Letter |

    Mark O'Driscoll, Andrew Jackson and colleagues report the identification of mutations in ORC1 in individuals with microcephalic primordial dwarfism. ORC1 encodes the largest subunit of the origin recognition complex.

    • Louise S Bicknell
    • , Sarah Walker
    • , Anna Klingseisen
    • , Tom Stiff
    • , Andrea Leitch
    • , Claudia Kerzendorfer
    • , Carol-Anne Martin
    • , Patricia Yeyati
    • , Nouriya Al Sanna
    • , Michael Bober
    • , Diana Johnson
    • , Carol Wise
    • , Andrew P Jackson
    • , Mark O'Driscoll
    •  & Penny A Jeggo
  • Letter |

    Andrew Jackson, Ernie Bongers and colleagues report the identification of mutations in five genes in individuals with Meier-Gorlin syndrome. The five genes, ORC1, ORC4, ORC6, CDT1 and CDC6, all encode components of the pre-replication complex.

    • Louise S Bicknell
    • , Ernie M H F Bongers
    • , Andrea Leitch
    • , Stephen Brown
    • , Jeroen Schoots
    • , Margaret E Harley
    • , Salim Aftimos
    • , Jumana Y Al-Aama
    • , Michael Bober
    • , Paul A J Brown
    • , Hans van Bokhoven
    • , John Dean
    • , Alaa Y Edrees
    • , Murray Feingold
    • , Alan Fryer
    • , Lies H Hoefsloot
    • , Nikolaus Kau
    • , Nine V A M Knoers
    • , James MacKenzie
    • , John M Opitz
    • , Pierre Sarda
    • , Alison Ross
    • , I Karen Temple
    • , Annick Toutain
    • , Carol A Wise
    • , Michael Wright
    •  & Andrew P Jackson
  • Letter |

    Mark Samuels and colleagues report the identification of mutations in ORC4, which encodes a component of the origin recognition complex, in individuals with Meier-Gorlin syndrome. The features of this syndrome include small stature, small external ears and small or absent patellae.

    • Duane L Guernsey
    • , Makoto Matsuoka
    • , Haiyan Jiang
    • , Susan Evans
    • , Christine Macgillivray
    • , Mathew Nightingale
    • , Scott Perry
    • , Meghan Ferguson
    • , Marissa LeBlanc
    • , Jean Paquette
    • , Lysanne Patry
    • , Andrea L Rideout
    • , Aidan Thomas
    • , Andrew Orr
    • , Chris R McMaster
    • , Jacques L Michaud
    • , Cheri Deal
    • , Sylvie Langlois
    • , Duane W Superneau
    • , Sandhya Parkash
    • , Mark Ludman
    • , David L Skidmore
    •  & Mark E Samuels
  • Letter |

    Birgitte Lane and colleagues show that Ferguson-Smith disease, an autosomal dominant skin cancer condition characterized by the development of multiple self-healing tumors, is caused by a disease-specific spectrum of mutations in TGFBR1.

    • David R Goudie
    • , Mariella D'Alessandro
    • , Barry Merriman
    • , Hane Lee
    • , Ildikó Szeverényi
    • , Stuart Avery
    • , Brian D O'Connor
    • , Stanley F Nelson
    • , Stephanie E Coats
    • , Arlene Stewart
    • , Lesley Christie
    • , Gabriella Pichert
    • , Jean Friedel
    • , Ian Hayes
    • , Nigel Burrows
    • , Sean Whittaker
    • , Anne-Marie Gerdes
    • , Sigurd Broesby-Olsen
    • , Malcolm A Ferguson-Smith
    • , Chandra Verma
    • , Declan P Lunny
    • , Bruno Reversade
    •  & E Birgitte Lane

Technical Reports

  • Technical Report |

    Sakari Kauppinen and colleagues report a method for silencing miRNA families in vivo. They find that seed-targeting 8-mer LNA oligonucleotides, termed tiny LNAs, can lead to long-term miRNA silencing in normal tissues and breast tumors in mice.

    • Susanna Obad
    • , Camila O dos Santos
    • , Andreas Petri
    • , Markus Heidenblad
    • , Oliver Broom
    • , Cristian Ruse
    • , Cexiong Fu
    • , Morten Lindow
    • , Jan Stenvang
    • , Ellen Marie Straarup
    • , Henrik Frydenlund Hansen
    • , Troels Koch
    • , Darryl Pappin
    • , Gregory J Hannon
    •  & Sakari Kauppinen

Addendum

Addendum

Corrigenda

  • Corrigendum |

    • Hyun Hor
    • , Zoltán Kutalik
    • , Yves Dauvilliers
    • , Armand Valsesia
    • , Gert J Lammers
    • , Claire E H M Donjacour
    • , Alex Iranzo
    • , Joan Santamaria
    • , Rosa Peraita Adrados
    • , José L Vicario
    • , Sebastiaan Overeem
    • , Isabelle Arnulf
    • , Ioannis Theodorou
    • , Poul Jennum
    • , Stine Knudsen
    • , Claudio Bassetti
    • , Johannes Mathis
    • , Michel Lecendreux
    • , Geert Mayer
    • , Peter Geisler
    • , Antonio Benetó
    • , Brice Petit
    • , Corinne Pfister
    • , Julie Vienne Bürki
    • , Gérard Didelot
    • , Michel Billiard
    • , Guadalupe Ercilla
    • , Willem Verduijn
    • , Frans H J Claas
    • , Peter Vollenwider
    • , Gerard Waeber
    • , Dawn M Waterworth
    • , Vincent Mooser
    • , Raphaël Heinzer
    • , Jacques S Beckmann
    • , Sven Bergmann
    •  & Mehdi Tafti
  • Corrigendum |

    • Benjamin F Voight
    • , Laura J Scott
    • , Valgerdur Steinthorsdottir
    • , Andrew P Morris
    • , Christian Dina
    • , Ryan P Welch
    • , Eleftheria Zeggini
    • , Cornelia Huth
    • , Yurii S Aulchenko
    • , Gudmar Thorleifsson
    • , Laura J McCulloch
    • , Teresa Ferreira
    • , Harald Grallert
    • , Najaf Amin
    • , Guanming Wu
    • , Cristen J Willer
    • , Soumya Raychaudhuri
    • , Steve A McCarroll
    • , Claudia Langenberg
    • , Oliver M Hofmann
    • , Josée Dupuis
    • , Lu Qi
    • , Ayellet V Segrè
    • , Mandy van Hoek
    • , Pau Navarro
    • , Kristin Ardlie
    • , Beverley Balkau
    • , Rafn Benediktsson
    • , Amanda J Bennett
    • , Roza Blagieva
    • , Eric Boerwinkle
    • , Lori L Bonnycastle
    • , Kristina Bengtsson Boström
    • , Bert Bravenboer
    • , Suzannah Bumpstead
    • , Noisël P Burtt
    • , Guillaume Charpentier
    • , Peter S Chines
    • , Marilyn Cornelis
    • , David J Couper
    • , Gabe Crawford
    • , Alex S F Doney
    • , Katherine S Elliott
    • , Amanda L Elliott
    • , Michael R Erdos
    • , Caroline S Fox
    • , Christopher S Franklin
    • , Martha Ganser
    • , Christian Gieger
    • , Niels Grarup
    • , Todd Green
    • , Simon Griffin
    • , Christopher J Groves
    • , Candace Guiducci
    • , Samy Hadjadj
    • , Neelam Hassanali
    • , Christian Herder
    • , Bo Isomaa
    • , Anne U Jackson
    • , Paul R V Johnson
    • , Torben Jørgensen
    • , Wen H L Kao
    • , Norman Klopp
    • , Augustine Kong
    • , Peter Kraft
    • , Johanna Kuusisto
    • , Torsten Lauritzen
    • , Man Li
    • , Aloysius Lieverse
    • , Cecilia M Lindgren
    • , Valeriya Lyssenko
    • , Michel Marre
    • , Thomas Meitinger
    • , Kristian Midthjell
    • , Mario A Morken
    • , Narisu Narisu
    • , Peter Nilsson
    • , Katharine R Owen
    • , Felicity Payne
    • , John R B Perry
    • , Ann-Kristin Petersen
    • , Carl Platou
    • , Christine Proença
    • , Inga Prokopenko
    • , Wolfgang Rathmann
    • , N William Rayner
    • , Neil R Robertson
    • , Ghislain Rocheleau
    • , Michael Roden
    • , Michael J Sampson
    • , Richa Saxena
    • , Beverley M Shields
    • , Peter Shrader
    • , Gunnar Sigurdsson
    • , Thomas Sparsø
    • , Klaus Strassburger
    • , Heather M Stringham
    • , Qi Sun
    • , Amy J Swift
    • , Barbara Thorand
    • , Jean Tichet
    • , Tiinamaija Tuomi
    • , Rob M van Dam
    • , Timon W van Haeften
    • , Thijs van Herpt
    • , Jana V van Vliet-Ostaptchouk
    • , G Bragi Walters
    • , Michael N Weedon
    • , Cisca Wijmenga
    • , Jacqueline Witteman
    • , The MAGIC investigators
    • , The GIANT Consortium
    • , Richard N Bergman
    • , Stephane Cauchi
    • , Francis S Collins
    • , Anna L Gloyn
    • , Ulf Gyllensten
    • , Torben Hansen
    • , Winston A Hide
    • , Graham A Hitman
    • , Albert Hofman
    • , David J Hunter
    • , Kristian Hveem
    • , Markku Laakso
    • , Karen L Mohlke
    • , Andrew D Morris
    • , Colin N A Palmer
    • , Peter P Pramstaller
    • , Igor Rudan
    • , Eric Sijbrands
    • , Lincoln D Stein
    • , Jaakko Tuomilehto
    • , Andre Uitterlinden
    • , Mark Walker
    • , Nicholas J Wareham
    • , Richard M Watanabe
    • , Gonçalo R Abecasis
    • , Bernhard O Boehm
    • , Harry Campbell
    • , Mark J Daly
    • , Andrew T Hattersley
    • , Frank B Hu
    • , James B Meigs
    • , James S Pankow
    • , Oluf Pedersen
    • , H-Erich Wichmann
    • , Inês Barroso
    • , Jose C Florez
    • , Timothy M Frayling
    • , Leif Groop
    • , Rob Sladek
    • , Unnur Thorsteinsdottir
    • , James F Wilson
    • , Thomas Illig
    • , Philippe Froguel
    • , Cornelia M van Duijn
    • , Kari Stefansson
    • , David Altshuler
    • , Michael Boehnke
    •  & Mark I McCarthy

Erratum

  • Erratum |

    • Dermot P B McGovern
    • , Agnès Gardet
    • , Leif Törkvist
    • , Philippe Goyette
    • , Jonah Essers
    • , Kent D Taylor
    • , Benjamin M Neale
    • , Rick T H Ong
    • , Caroline Lagacé
    • , Chun Li
    • , Todd Green
    • , Christine R Stevens
    • , Claudine Beauchamp
    • , Phillip R Fleshner
    • , Marie Carlson
    • , Mauro D'Amato
    • , Jonas Halfvarson
    • , Martin L Hibberd
    • , Mikael Lördal
    • , Leonid Padyukov
    • , Angelo Andriulli
    • , Elisabetta Colombo
    • , Anna Latiano
    • , Orazio Palmieri
    • , Edmond-Jean Bernard
    • , Colette Deslandres
    • , Daan W Hommes
    • , Dirk J de Jong
    • , Pieter C Stokkers
    • , Rinse K Weersma
    • , The NIDDK IBD Genetics Consortium
    • , Yashoda Sharma
    • , Mark S Silverberg
    • , Judy H Cho
    • , Jing Wu
    • , Kathryn Roeder
    • , Steven R Brant
    • , L Phillip Schumm
    • , Richard H Duerr
    • , Marla C Dubinsky
    • , Nicole L Glazer
    • , Talin Haritunians
    • , Andy Ippoliti
    • , Gil Y Melmed
    • , David S Siscovick
    • , Eric A Vasiliauskas
    • , Stephan R Targan
    • , Vito Annese
    • , Cisca Wijmenga
    • , Sven Pettersson
    • , Jerome I Rotter
    • , Ramnik J Xavier
    • , Mark J Daly
    • , John D Rioux
    •  & Mark Seielstad