Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Gene fusions arising from translocations make an important contribution to the development of cancer. A new study uses high-throughput sequencing to characterize such fusions at an unprecedented level of resolution.
Genome-wide association studies in Crohn's disease have convincingly identified multiple risk variants. Two new studies in ulcerative colitis, a related inflammatory bowel disease, now reveal a glimpse of the overlapping spectrum of risk variants, highlighting both the commonalities and the unique features of these disorders.
A new paper reports an individual with the major features of Prader-Willi syndrome (PWS) and a microdeletion in 15q11–q13 removing a cluster of small nucleolar RNAs (snoRNAs). This report provides virtually conclusive evidence that PWS is caused by loss of expression of the C/D box HBII-85 snoRNAs.
The X chromosome has been thought to be mostly silent after meiosis in males. A new study reports that this is not the case for a set of multicopy genes often arranged in giant palindromes and highly expressed in spermatids.
Digital clubbing has been recognized since the time of the ancient Greeks as a sign of systemic disease. Now, a new study identifies a role for prostaglandin E2 in the pathogenesis of digital clubbing observed in familial hypertrophic osteoarthropathy.