Volume 33 Issue 4, April 2003

Volume 33 Issue 4

Cover art: Photographer: Nicole Fournier Location: Manhattan, New York, USA

Editorial

News and Views

  • News & Views |

    Eed, a member of the Polycomb group family of chromatin regulators, acts early in mouse development to maintain imprinted X-chromosome inactivation in females. But does this protein also contribute to imprinting on mouse autosomes?

    • Anne C. Ferguson-Smith
    •  & Wolf Reik
  • News & Views |

    Recent papers have shown the feasibility of classifying humans into categorical populations from their genotypes. How can this be reconciled with the claim that human races are biologically meaningless, and what are the implications for medical genetics projects?

    • Francesc Calafell
  • News & Views |

    An altered form of an esterase has been implicated in the development of neurotoxicity after exposure to organophosphates. Mice deficient in this enzyme should be less susceptible to toxicity, but the opposite turns out to be the case.

    • James P. O'Callaghan
  • News & Views |

    Reliable identification of genetic variants that affect gene regulation is still a challenge in genomics and is expected to have an important role in the molecular characterization of complex traits. A new study describes a robust functional assay that detects the presence of cis-acting polymorphisms that regulate gene transcription.

    • Thomas J. Hudson
  • News & Views |

    For the detection of human gene mutations to have practical application, clear clinical descriptions of the affected individuals (as well as those clinically affected in whom mutations are not found) should be part of the publication.

    • Judith G. Hall
  • News & Views |

    Gene transfers from chloroplasts to the nucleus occur naturally over evolutionary time scales but have always been inferred from sequence comparisons, never directly observed. A notable new report has caught plastid-to-nucleus gene transfer in the act, providing exciting opportunities to study its mechanisitic details in the laboratory and its ecological implications in nature.

    • William Martin

Book Reviews

Commentaries

Brief Communications

  • Brief Communication |

    • Imke Puls
    • , Catherine Jonnakuty
    • , Bernadette H. LaMonte
    • , Erika L.F. Holzbaur
    • , Mariko Tokito
    • , Eric Mann
    • , Mary Kay Floeter
    • , Kimberly Bidus
    • , Dennis Drayna
    • , Shin J. Oh
    • , Robert H. Brown Jr
    • , Christy L. Ludlow
    •  & Kenneth H. Fischbeck
  • Brief Communication |

    • Judy Fantes
    • , Nicola K. Ragge
    • , Sally-Ann Lynch
    • , Niolette I. McGill
    • , J. Richard O. Collin
    • , Patricia N. Howard-Peebles
    • , Caroline Hayward
    • , Anthony J. Vivian
    • , Kathy Williamson
    • , Veronica van Heyningen
    •  & David R. FitzPatrick
  • Brief Communication |

    • Catherine Dodé
    • , Jacqueline Levilliers
    • , Jean-Michel Dupont
    • , Anne De Paepe
    • , Nathalie Le Dû
    • , Nadia Soussi-Yanicostas
    • , Roney S. Coimbra
    • , Sedigheh Delmaghani
    • , Sylvie Compain-Nouaille
    • , Françoise Baverel
    • , Christophe Pêcheux
    • , Dominique Le Tessier
    • , Corinne Cruaud
    • , Marc Delpech
    • , Frank Speleman
    • , Stefan Vermeulen
    • , Andrea Amalfitano
    • , Yvan Bachelot
    • , Philippe Bouchard
    • , Sylvie Cabrol
    • , Jean-Claude Carel
    • , Henriette Delemarre-van de Waal
    • , Barbara Goulet-Salmon
    • , Marie-Laure Kottler
    • , Odile Richard
    • , Franco Sanchez-Franco
    • , Robert Saura
    • , Jacques Young
    • , Christine Petit
    •  & Jean-Pierre Hardelin

New Technology

Article

Letters

Corrigendum