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Volume 39 Issue 7, July 2007

Cover art: Briefcase by Annie Pootoogook http://www.dorsetfinearts.com/artists.html From the Guild Shop (Toronto) http://www.craft.on.ca

Volume 39 Issue 7

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Editorial

  • Kevin Davies, the founding editor of Nature Genetics, recalls the perfect storm of events and personalities that governed the launch of the journal 15 years ago and its formative years. The journal offered a high-profile forum for the genetics community—and a bold new direction for Nature Publishing Group.

    • Kevin Davies
    Editorial

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Correspondence

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Book Review

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News & Views

  • Genome-wide association studies, exemplified by the Wellcome Trust Case Control Consortium and follow-up studies, have identified dozens of common variants robustly associated with common diseases, providing new clues about genetic architecture in humans. Finding all such loci, and fully defining genotype-phenotype correlation, will be a key to translating initial clues into pathophysiological understanding and clinical prediction.

    • David Altshuler
    • Mark Daly
    News & Views

  • Human genome-wide association studies pose a challenge in identifying significant disease associations from nearly half a million statistical tests. A new report describes an especially promising approach, recently applied to the Wellcome Trust Case Control Consortium data sets, that uses the correlated structure of genomic variation to impute genotypes at missing sites and to test association with both observed and imputed SNPs.

    • Andrew G Clark
    • Jian Li
    News & Views

  • The much-anticipated publication of the ENCODE pilot project, representing a detailed and comprehensive characterization of 1% of the human genome, has demonstrated how little we truly understand about how our genes are regulated. Transcripts are nearly everywhere, regulatory sequences remain poorly defined and evolutionary conservation is a surprisingly inadequate predictor of transcriptional features.

    • Steven Henikoff
    News & Views

  • The list of genetic diseases associated with dysfunction of primary cilia continues to expand. Two new studies add to this growing body of literature and provide a fascinating example of the clinical variability associated with ciliary disorders.

    • Kirk Mykytyn
    News & Views

  • Wnt signaling regulates several aspects of development and tissue homeostasis. Two new studies in this issue uncover the underlying mechanism for focal dermal hypoplasia, a multiorgan developmental disorder, and underscore the important role of Wnt proteins in ectodermal-mesodermal communication.

    • Amy S Paller
    News & Views
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Brief Communication

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Article

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Letter

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Technical Report

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Supplement

  • We are pleased to announce the publication of a supplement devoted to structural variation in the human genome.

    Supplement
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