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Volume 14 Issue 8, August 2018

Volume 14 Issue 8

Diversity in bloom

In Rauwolfia serpentina (pictured) and other alkaloid-producing plants, sarpagan bridge enzyme can catalyze either cyclization or aromatization, depending on the substrate, to produce diverse classes of monoterpene indole alkaloid products.

See O’Connor et al.

Image: Dinodia Photos/Alamy Stock Photo. Cover Design: Erin Dewalt.

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    Monitoring MHC-I dynamics upon binding to its chaperone TAPBPR helps us understand how optimal peptide sequences are selected for presentation and coordinated with release of the chaperone from the ternary peptide–MHC-I–TAPBPR complex.

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    Calcium channels are crucial regulators of a broad range of biological processes. A photoswitchable chemical probe allows the opening and closing of these channels with unprecedented temporal resolution, providing new opportunities to study calcium-dependent signaling pathways in real time.

    • Marc Vendrell

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