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Volume 14 Issue 8, August 2018

Volume 14 Issue 8

Diversity in bloom

In Rauwolfia serpentina (pictured) and other alkaloid-producing plants, sarpagan bridge enzyme can catalyze either cyclization or aromatization, depending on the substrate, to produce diverse classes of monoterpene indole alkaloid products.

See O’Connor et al.

Image: Dinodia Photos/Alamy Stock Photo. Cover Design: Erin Dewalt.

Research Highlights

News & Views

  • News & Views |

    Adaptive survival signaling can promote resistance to individual kinase inhibitors. A new study used a pathway-based approach to characterize shared kinome-wide rewiring mechanisms across multiple kinase inhibitors and developed rational drug-combination approaches that target cross-talk between two signaling pathways.

    • Vinayak Palve
    • Brent M. Kuenzi
    • Uwe Rix
  • News & Views |

    Monitoring MHC-I dynamics upon binding to its chaperone TAPBPR helps us understand how optimal peptide sequences are selected for presentation and coordinated with release of the chaperone from the ternary peptide–MHC-I–TAPBPR complex.

    • Tim Elliott
  • News & Views |

    Calcium channels are crucial regulators of a broad range of biological processes. A photoswitchable chemical probe allows the opening and closing of these channels with unprecedented temporal resolution, providing new opportunities to study calcium-dependent signaling pathways in real time.

    • Marc Vendrell


Brief Communications



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