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The diversity of biological pathways that are regulated by protein post-translational modification with O-GlcNAc requires community engagement to develop and apply tools to probe the biological and disease-relevant functions of these modifications.
Using extensive knowledge about the structures and mechanisms of genetically encoded fluorescent biosensors, this Perspective provides guidelines to aid and accelerate the development of an increasingly broad range of high-performance imaging tools.
This Perspective summarizes the known types of ligand-controlled ribozymes and riboswitches and discusses the reasons why allosteric ribozymes formed by fusion of RNA enzymes and RNA aptamers are rare in today’s biological systems.
This Perspective summarizes the recent advances in the structural diversity of amyloid fibrils and discusses the roles of post-translational modifications and chemical cofactors in the conformational determination of fibril polymorphs.
This Perspective introduces chemical biologists to potentially useful nanotechnologies, aims to inspire nanotechnologists to address questions relevant to chemical biology, and identifies possible opportunities for the two fields to collaborate.
