As biochemistry ventures out from its reductionist roots, concentration effects and high surface-to-volume ratios will challenge our current understanding of biological systems, with colloidal and surface chemistry leading to new insights and approaches. How must our thinking change, what new tools will we need and how will these new tools be developed?
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T.L. is co-owner of Spin Analytical, which is producing the new analytical ultracentrifuge.
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Laue, T., Demeler, B. A postreductionist framework for protein biochemistry. Nat Chem Biol 7, 331–334 (2011). https://doi.org/10.1038/nchembio.575
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DOI: https://doi.org/10.1038/nchembio.575