Multiple optogenetic technologies are required to control biological activity simultaneously with different colors of light. Optimizing a near-infrared-induced heterodimerization system, which can be combined with blue-light-controlled domains, enables precise spatiotemporal control of target molecules in live mammalian cells.
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References
Nagel, G. et al. Proc. Natl. Acad. Sci. USA 100, 13940–13945 (2003).
Kennedy, M.J. et al. Nat. Methods 7, 973–975 (2010).
Wu, Y.I. et al. Nature 461, 104–108 (2009).
Gautier, A. et al. Nat. Chem. Biol. 10, 533–541 (2014).
Redchuk, T.A., Omelina, E.S., Chernov, K.G. & Verkhusha, V.V. Nat. Chem. Biol. 13, 633–639 (2017).
Reichhart, E., Ingles-Prieto, A., Tichy, A.M., McKenzie, C. & Janovjak, H. Angew. Chem. Int. Ed. Engl. 55, 6339–6342 (2016).
Shimizu-Sato, S., Huq, E., Tepperman, J.M. & Quail, P.H. Nat. Biotechnol. 20, 1041–1044 (2002).
Levskaya, A., Weiner, O.D., Lim, W.A. & Voigt, C.A. Nature 461, 997–1001 (2009).
Müller, K. et al. Chem. Commun. (Camb.) 49, 8970–8972 (2013).
Kaberniuk, A.A., Shemetov, A.A. & Verkhusha, V.V. Nat. Methods 13, 591–597 (2016).
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Kawano, F., Shi, F. & Yazawa, M. Switching with red and blue. Nat Chem Biol 13, 573–574 (2017). https://doi.org/10.1038/nchembio.2387
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DOI: https://doi.org/10.1038/nchembio.2387