Antibiotic–resistant bacteria are an increasingly important public health concern and the development of new antibiotic drugs — particularly those that act by new mechanisms — is thus of great importance. Now, Benjamin Davis, Hagan Bayley and co-workers have used a single-molecule electrochemical technique to identify potential blockers of the channel-forming proteins that export capsular polysaccharides, which form part of the bacterial defence system, from the cell. The cover image shows the eight-fold symmetrical cyclodextrinbased inhibitor binding to the octameric channel-forming protein.
Article p651; News & Views p642
IMAGE: LEON HARRINGTON AND LINGBING KONG
COVER DESIGN: ALEX WING