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Volume 5 Issue 11, November 2021

Phototherapeutics are an attractive approach towards targeted therapies. The ability to uncage drugs in localised sites through light activation could enable controlled dosing and reduced side effects. See Vickerman et al.

Image: David Lawrence and Carl Conway [Note: The image credit originally published was incorrect; it has now been updated.]

Volume 5 Issue 11

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Research Highlights

  • A geometrically constrained phosphine bearing a tridentate NNS pincer ligand can afford thermoneutral activation of N−H in ammonia.

    • Stacey-Lynn Paiva
    Research Highlight

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  • The combination of mass spectroscopy-based proteomics with molecular dynamics enables the in-depth study of metallothioneine-Zn(II) binding mechanisms, critical to cell homeostasis and Zn(II) ion buffering.

    • Colette Whitfield
    Research Highlight
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Reviews

  • Uncontrolled bleeding is a major cause of death, incentivizing the development of biomaterials that aid haemostasis and wound healing. This Review highlights the active components and forms of haemostatic materials, with a focus on their chemical design, and considers future trends in their development.

    • Baolin Guo
    • Ruonan Dong
    • Meng Li
    Review Article

  • The exploitation of non-covalent interactions in carbohydrate chemistry is gaining traction. This Review summarizes recent developments in harnessing non-covalent interactions in selective carbohydrate synthesis, and highlights future directions.

    • Charles C. J. Loh
    Review Article

  • The current scope and limitations, path to the clinic and therapeutic applications of long-wavelength-responsive, light-activated drugs are discussed in this Review.

    • Brianna M. Vickerman
    • Emilia M. Zywot
    • David S. Lawrence
    Review Article
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