Histone H1.0 links cell mechanics to chromatin structure

Hu et al. describe how histone H1.0 regulates cellular responses to mechanical stimulation, inducing myofibroblast activation in the heart and linking force generation to nuclear organization and gene transcription.

See Hu et al.

Neutralizing gremlins protects against myocarditis

Perez-Shibayama et al. report that restoring BMP4 signaling with antibodies that neutralize the BMP inhibitors gremlin-1 and gremlin-2 can ameliorate myocarditis by reducing immune cell infiltration, the production of pathogenic cytokines, and pro-inflammatory activity in fibroblasts.

See Perez-Shibayama et al.

A bispecific antibody to treat bleeding disorders

Gandhi, Zivkovic, Østergaard et al. describe a bispecific antibody, HMB-001, that can be used for the potential prophylactic treatment of patients with genetic bleeding disorders.

See Ghandhi et al.

Shift in cardiometabolic and renal phenotypes in the US population

Lhoste et al. show that cardiometabolic and renal traits of the US population have shifted from phenotypes with high blood pressure and high cholesterol towards poor kidney function, hyperglycemia and severe obesity.

See Lhoste et al.