Parsing glioblastoma heterogeneity for redefined classification
Analysis of glioblastoma heterogeneity can classify the disease according to four fundamental functional properties, depicted here as branches of one tree. Genetic alterations common to these four subtypes are within the glioblastoma trunk, but each subtype diverges through distinct genetic lesions and gene-expression programs that incorporate prognostic and therapeutic attributes.
See Garofano et al. See also the articles by Richards et al. and Castellan et al., and the related News & Views by Hubert and Lathia