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Volume 1 Issue 7, July 2020

Volume 1 Issue 7

Stromal heterogeneity unraveled

Unravelling the dynamic changes in cancer-associated fibroblast subpopulations during breast cancer progression.

See Friedman et al..

Image: Genia Brodsky & Scherz-Shouval lab, Weizmann Institute of Science. Cover Design: Allen Beattie.

Editorial

  • Editorial |

    Government policies that threaten the international mobility of biomedical students, researchers and physicians stand to imperil scientific progress and innovation at a time when supporting them is paramount.

News & Views

  • News & Views |

    The approval of anti-TNF therapy for colitis over 20 years ago represented a paradigm shift for the treatment of this disease. Anti-TNF therapy is now shown to prevent colitis-associated colon cancer in mice by modifying the gut microbiota composition and transcriptional activity, including genes in Escherichia coli that control colibactin synthesis.

    • Giorgio Trinchieri
  • News & Views |

    Natural killer (NK) cells serve a critical role in the control of metastasis. NK cells are now shown to preferentially control monoclonal metastases derived from single circulating tumor cells rather than polyclonal metastases derived from cell clusters. These findings provide further evidence that NK cells are linked to metastatic cell immunoediting.

    • Kyohei Nakamura
    • Mark J. Smyth

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