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Malanchi and colleagues demonstrate that irradiation in healthy lung tissue leads to an alveolar repair response orchestrated by neutrophils and Notch signaling that promotes metastatic colonization of disseminated tumor cells in the lung.
Gavert et al. develop an organotypic platform to define individual-specific therapies, show that it can reflect in vivo PDX responses and find that combined MEK and Src inhibition is effective in a large panel of human colorectal tumors.
Xie et al. show that loss of SETD2-mediated H3K36me3 promotes kidney cancer metastasis through epigenetic remodeling and uncover actionable therapeutic vulnerabilities in these tumors.
Saur and colleagues perform a high-throughput combinatorial drug screen and identify a synergistic combination between nintedanib and trametinib that sensitizes mesenchymal PDAC to immune checkpoint blockade.
Sun and colleagues identify lnc-CTHCC, a cancer-testis lncRNA that binds to hnRNP K, activates YAP1 transcription and promotes hepatocellular carcinogenesis.