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Cover Legend: Cerebral 5-HT4 receptor binding before and after intervention with fluxotine: Cerebral 5-HT4 receptor binding as measured with 11C-SB207145 PET in a healthy volunteer before (left) and after (right) 3 weeks of intervention with fluxotine. Intervention is associated with a decline in 5-HT4 receptor binding. 3-D surface rendering is done on the basis of the corresponding MR brain image and the brain image is sliced to illustrate the higher 5-HT4R binding in striatum. For more info on this topic, please refer to the article by Haahr et al. on pages 427–432.