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NB: AS OF JANUARY 1, 2023 THIS JOURNAL IS PUBLISHED WITH ELSEVIER: https://www.sciencedirect.com/journal/mucosal-immunology

Volume 14 Issue 6, November 2021

This cover image shows multiplex IHC imaging of duodenal biopsies from SARSCoV-2 infected individuals stained with antibodies against CD8α (green), EpCAM (red) and Ki67 (cyan). Nuclei were counterstained with DAPI (blue). The image indicates the histomorphological changes in the small intestinal epithelium of COVID-19 patients, characterized by an accumulation of intraepithelial CD8+ T cells, and regenerative proliferation subsequent to epithelial apoptosis. Please see the article in this issue, pages 1381–1392.

Volume 14 Issue 6

Comment

  • Recent findings by Felton et al. and Qiu et al. unveil the importance of the transcription factor Aiolos for tissue-resident eosinophils and group 2 innate lymphoid cells (ILC2s). The authors find that Aiolos regulates the transcriptomic profile and chromatin landscape, both of which are essential for eosinophil and ILC2 localisation in tissues, as well as their function. These studies place Aiolos as a molecular guardian that regulates tissue-resident type 2 innate cells.

    • Aidil Zaini
    • Colby Zaph
    Comment

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