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The January 2012 special issue presents two important strategies for generating potent and lasting anti-tumor immunity. The first strategy is to subvert immune suppressive networks in the tumor microenvironment. The second strategy is to optimize conventional and anti-biological modalities to directly target tumor and adjacent tumor tissue, and mobilize and expand anti-tumor immunity in the tumor microenvironment which results in tumor eradication. Further background information on this important topic is available through the accompanying web focus which links to related articles from across Springer Nature.
In recent decades enormous effort has been made to elucidate the pathogenesis of autoimmune and autoinflammatory diseases. Autoimmunity is a multifactorial process in which genetic, immunological, environmental and hormonal factors act in concert, representing what was termed some years ago the “mosaic of autoimmunity”. The May 2011 Special Issue on Cutting Edge Issues in Immunology and Autoimmunity summarizes our current understanding of this complex mosaic. The accompanying selection of recent articles from across the Springer Nature provide further insight into this topic.
This collection of review articles covers recent advances in the understanding of the mechanisms which govern stem cell retention in the bone marrow and their mobilization into peripheral blood. An invaluable resource for practicing clinicians, laboratory scientists, and other hematologists. This Focus is dedicated to Prof. Ernest McCulloch who opened the way to modern stem cell studies and remains a vivid figure for all those working in the field today.
This collection of review articles covers recent advances in the biology and treatment of multiple myeloma. The collection also includes authoritative consensus statements on controversial and evolving areas including diagnostic and response criteria, molecular classification, and new laboratory tests. These reviews will be an invaluable resource for practicing clinicians, laboratory scientists, and other hematologists.
This Focus is devoted to Genomics and to the unravelling of the molecular basis of leukemias and germane diseases. As we enter a new era in science, compelling us to reinterpret the meaning of our experiments and leading us to new categories of diagnostic and prognostic groups, we are obliged to embrace an utterly staggering number and complex network of genes.
This focus elegantly and masterly covers all the most up-to-date steps in BCR-ABL-negative Myeloproliferative Neoplasms and opens the door to a detailed molecular understanding of the multi-step nature of blood cancers. The topic is covered from several perspectives including history, disease classification, genetics, signaling, drug development, treatment options, and MPN stem cell biology.
This focus offers a compendium of articles providing an exciting overview and an important source of timely information on the state-of-the-art research on a broad range of clinical topics related to RIC.