Abstract
Two new antibiotic depsipeptides, unnarmicins C (1) and A (2), were isolated from the fermentation broth of a marine bacterium, Photobacterium sp. strain MBIC06485. The structure of 1 was established by spectroscopic studies and chiral analyses of its chemical degradation/conversion products, and that of 2 by comparing its NMR, MS, and CD data with those of 1. Both compounds selectively inhibited the growth of two strains belonging to the genus Pseudovibrio, one of the most prevalent genera in the marine environments within the class Alphaproteobacteria.
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Venter JC, Remington K, Heidelberg JF, Halpen AL, Rusch D, Eisen JA, Wu D, Paulsen I, Nelson KE, Nelson W, Fouts DE, Levy S, Knap AH, Lomas MW, Nealson K, White O, Peterson J, Hoffman J, Parsons R, Baden-Tillson H, Pfannkoch C, Rogers Y-H, Smith HO . Environmental genome shot sequence of the Sargasso Sea. Science 304: 66–74 ( 2004)
Berdy J . Bioactive Microbial Metabolites. A Personal View. J Antibiot 58: 1–26 ( 2005)
Kelecom A . Secondary metabolites from marine microorganisms. An Acad Bras Cienc 74: 151–170 ( 2002)
Jensen PR, Mincer TJ, Williams PG, Fenical W . Marine actinomycete diversity and natural product discovery. Antonie Van Leeuwenhoek 87: 43–48 ( 2005)
Lam KS . Discovery of novel metabolites from marine actinomycetes. Curr Opin Microbiol 9: 245–251 ( 2006)
Matsuo Y, Kanoh K, Imagawa H, Adachi K, Nishizawa M, Shizuri Y . Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. J Antibiot 60: 256–260 ( 2007)
Matsuo Y, Kanoh K, Yamori T, Kasai H, Katsuta A, Adachi K, Shin-Ya K, Shizuri Y . Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. J Antibiot 60: 251–255 ( 2007)
Kanoh K, Matsuo Y, Adachi K, Imagawa H, Nishizawa M, Shizuri Y . Mechercharmycins A and B, cytotoxic substances from marine-derived Thermoactinomyces sp. YM3-251. J Antibiot 58: 289–292 ( 2005)
Imamura N, Nishijima M, Takadera T, Adachi K, Sakai M, Sano H . New anticancer antibiotics pelagiomicins, produced by a new marine bacterium Pelagiobacter variabilis. J Antibiot 50: 8–12 ( 1997)
Yoshikawa K, Takadera T, Adachi K, Nishijima M, Sano H . Korormicin, a novel antibiotic specifically active against marine Gram-negative bacteria, produced by a marine bacterium. J Antibiot 50: 949–953 ( 1997)
Imamura N, Adachi K, Sano H . Magnesidin A, a component of marine antibiotic magnesidin, produced by Vibrio gazogenes ATCC29988. J Antibiot 47: 257–261 ( 1994)
Imamura N, Motoike I, Noda M, Adachi K, Konno A, Fukami H . Argimicin A, a novel anti-cyanobacterial compound produced by an algae-lysing bacterium. J Antibiot 53: 1317–1319 ( 2000)
Yamaguchi T, Kobayashi Y, Adachi K, Imamura N . Argimicins B and C, new anti-cyanobacterial compounds produced by Sphingomonas sp. M-17. J Antibiot 56: 655–657 ( 2003)
Kanoh K, Kamino K, Leleo G, Adachi K, Shizuri Y . Pseudoalterobactins A and B, new siderophores excreted by marine bacterium Pseudoalteromonas sp. KP20-4. J Antibiot 56: 871–875 ( 2003)
Jang JH, Kanoh K, Adachi K, Matsuda S, Shizuri Y . Tenacibactins A∼D, hydroxamate siderophores from a marine-derived bacterium, Tenacibaculum sp. A4K-17. J Nat Prod 70: 563–566 ( 2007)
Izumida H, Adachi K, Mihara A, Yasuzawa T, Sano H . Hydroxyakalone, a novel xanthine oxidase inhibitor produced by a marine bacterium, Agrobacterium aurantiacum. J Antibiot 50: 916–918 ( 1997)
Haygood MG . Light organ symbioses in fishes. Crit Rev Microbiol 19: 191–216 ( 1993)
Matsuura S, Odaka M, Sugimoto T, Goto T . The structure of pteridines from Photobacterium. Chem Lett 4: 343–346 ( 1973)
Suzuki A, Goto M . Photolumazines, new naturally occurring inhibitors of riboflavine synthetase. Biochim Biophys Acta 313: 229–234 ( 1973)
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Oku, N., Kawabata, K., Adachi, K. et al. Unnarmicins A and C, New Antibacterial Depsipeptides Produced by Marine Bacterium Photobacterium sp. MBIC06485. J Antibiot 61, 11–17 (2008). https://doi.org/10.1038/ja.2008.103
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DOI: https://doi.org/10.1038/ja.2008.103
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