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Cover Credit: The remarkable tools of modern genetics have the potential to reduce costs of gene-based therapies and make them accessible to all who need them. The high prices for some recently approved therapies underscore the uncertain success of that goal. Cover created with BioRender.com by Caitlin Wheeler (PhD Candidate), Division of Human Genetics, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, South Africa, Bioengineering and Integrated Genomics Group, Council for Scientific and Industrial Research, Pretoria, South Africa.