Figure 8 - Schematic of vanilloid receptor 1 (VR1).

It consists of six transmembrane domains (blue cylinders) along with a calcium-permeable pore-loop (green). Outer (o) and inner (i) plasma membrane leaflets are present. The hydrophilic amino-terminal segment contains three ankyrin repeat domains (A) followed by an N-terminus (N). One of the transmembrane domains also contains a carboxy terminus (C), which does not have any recognizable motifs. (Source: Caterina et al.,⁵⁸ with permission from Macmillan Publishers Ltd.)