Figure 10 - H₂O₂ and LES.

a: Human LES muscle mounted in muscle chambers, near conditions of optimum force development, developed steady tension after 3 to 4 hours (normal). An esophagitis specimen (esophagitis), obtained from an organ donor, had lower tone than normal strips, but tone increased after incubation in catalase.suggesting that H₂O₂ may be responsible for the reduced tone in esophagitis. b: Treatment of normal LES muscle with IL-1 (200 U/mL, 2 hours) increased H₂O₂, and H₂O₂ levels were fourfold higher in LES muscle from the esophagitis specimen compared with normal muscle. Means + SE are shown for three normal LES samples. (Source: Cheng et al.,⁸⁶ with permission from American Gastroenterological Association.)