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Interleukin-10 polymorphisms in Spanish type 1 diabetes patients

Genes & Immunity volume 5, pages 306–309 (2004)Cite this article

Abstract

The MHC accounts for half of the genetic susceptibility to type 1 diabetes (T1D). Evidence suggests that an imbalance in Th1/Th2 responses may play a key role in the development of autoimmune diabetes. Since interleukin-10 (IL-10) modulates immune and inflammatory responses and has been implicated in many autoimmune diseases, it seemed interesting to examine whether IL-10 polymorphisms participate in diabetes predisposition. In fact, this is the first association study investigating the role of the IL- 10 polymorphisms in susceptibility to T1D in a Caucasian population. Three promoter polymorphisms (−1082G/A, −819C/T, −592C/A) and two CA-repeat microsatellites (IL-10R and IL-10G at –4 and –1.1 kb) were tested in a case–control study with 294 T1D patients and 574 healthy controls. Our results prove a minor role of IL-10 in the autoimmune diabetes risk, although we found the same association trend with IL-10G*12 allele as was previously observed for multiple sclerosis and rheumatoid arthritis.

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Acknowledgements

We thank Drs Carlos Maluenda and José M Ibarra for their help in recruiting patients for this study, and Carmen Martínez for expert technical assistance. This work has been supported by MCYT “Ramón y Cafal” and FIS 01/F011.

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Authors and Affiliations

  1. Immunology Department, Hospital Universitario San Carlos, Madrid, Spain

    E Urcelay, J L Santiago, A Martínez, A Figueredo, M Fernández-Arquero & E G de la Concha

  2. Endocrinology Department, Hospital Ramón y Cajal, Madrid, Spain

    H de la Calle

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  1. E Urcelay
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  2. J L Santiago
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  3. H de la Calle
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  4. A Martínez
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  5. A Figueredo
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  6. M Fernández-Arquero
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  7. E G de la Concha
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Correspondence to E Urcelay.

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Urcelay, E., Santiago, J., de la Calle, H. et al. Interleukin-10 polymorphisms in Spanish type 1 diabetes patients. Genes Immun 5, 306–309 (2004). https://doi.org/10.1038/sj.gene.6364071

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