Abstract
RNA performs a remarkable range of functions in all cells. In addition to its central role in information transfer from DNA to protein, it is essential for functions as diverse as RNA processing, chromosome end-maintenance and dosage compensation. The versatility of RNA derives from its unique ability to use direct readout via base-pairing for sequence specific targeting (or templating) in combination with its capacity to form elaborate three dimensional structures. Such structures can perform catalysis or serve as protein recognition surfaces. In this short review, we attempt to give a flavor for the diversity of functional RNAs in the cell and highlight, using selected examples, two quite distinct activities, catalysis and sequence specific targeting. Within each section, we discuss how the lessons we have learned from these systems may apply to other, less well understood, RNAs.
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References
Smith, C.M. & Steitz, J.A. Cell 89, 669–672 (1997).
Tollervey, D. & Kiss, T. Curr. Opin. Cell Biol. 9, 337–342 (1997).
Ganot, P., Bortolin, M.-L. & Kiss, T. Cell 89, 799–809 (1997).
Moss, E.G. Curr. Biol. 10, R436–R439 (2000).
Eddy, S.R. Curr. Opin. Genet. Dev. 9, 695–699 (1999).
Simpson, L. In The RNA world II (eds Gesteland, R.F., Cech, T.R. & Atkins, J.F.) 585–608 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York; 1999).
Delihas, N. J. Molec. Microbiol. 15, 411–414 (1995).
Yu, Y.-T., Scharl, E.C., Smith, C.M. & Steitz, J.A. In The RNA world II (eds Gesteland, R.F., Cech, T.R. & Atkins, J.F.) 487–524 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York; 1999).
Tarn, W.-Y. & Steitz, J.A. Trends Biochem. Sci. 22, 132–137 (1997).
Cech, T.R. In The RNA world (eds Gesteland, R.F. & Atkins, J.F.) 239–269 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York; 1993).
Doherty E.A. & Doudna J.A. Annu. Rev. Biochem. 69, 597–615 (2000).
Westhof E. & Fritsch V. Structure Folding Des. 8, R55–65 (2000).
Woodson, S.A. Cell. Mol. Life Sci. 57, 796–808 (2000).
Treiber, D.K. & Williamson, J.R. Curr. Opin. Struct. Biol. 9, 339–345 (1999).
Moore, P.B. In The RNA world II (eds Gesteland, R.F., Cech, T.R. & Atkins, J.F.) 381–401 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York; 1999).
Puglisi, J.D. Blanchard, S.C. & Green, R. Nature Struct. Biol. 7, 855–861 (2000).
Collins, C.A. and Guthrie C . Nature Struct. Biol. 7, 850–854 (2000).
Sigurdsson, S.T., Thomson, J.B. & Eckstein, F. In RNA structure and function (eds Simons, R.W. & Grunberg-Manago, M.) 339–376 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York; 1998).
McKay, D.B. & Wedekind, J.E. In The RNA world II (eds Gesteland, R.F., Cech, T.R. & Atkins, J.F.) 265–286 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York; 1999).
Kennell, J.C. et al. Genes Dev. 9, 294–303 (1995).
Pan, T., Long, D.M. & Uhlenbeck, O.C. In The RNA world (eds Gesteland, R.F. & Atkins, J.F.) 271–302 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York; 1993).
Yarus, M. FASEB J. 7, 31–39 (1993).
Steitz, T.A. & Steitz, J.A. Proc. Natl. Acad. Sci. USA 90, 6498–6502 (1993).
Narlikar, G.J. & Herschlag, D. Annu. Rev. Biochem. 66, 19–59 (1997).
Shan, S., Yoshida, A., Sun, S., Piccirilli, J.A. & Herschlag, D. Proc. Natl. Acad. Sci. USA 96, 12299–12304 (1999).
Perrotta, A.T., Shih, I. & Been, M.D. Science 286, 123–126 (1999).
Nakano, S., Chadalavada, D.M. & Bevilacqua, P.C. Science 287, 1493–1497 (2000).
Wilson, D.S. & Szostak, J.W. Annu. Rev. Biochem. 68, 611–647 (1999).
Lambowitz, A.M., Caprara, M.G., Zimmerly, S. & Perlman, P.S. In The RNA world II (eds Gesteland, R.F., Cech, T.R. & Atkins, J.F.) 451–485 (Cold Spring Harbor Laboratory Press, New York; 1999).
Weeks KM. Curr. Opin. Struct. Biol. 7, 3363–42 (1997).
Woodson, S.A. Curr. Biol. 6, 23–25 (1996).
Herschlag, D. J. Biol. Chem. 270, 20871–20874 (1997).
Peluso, P. et al. Science 288, 1640–1643 (2000).
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Caprara, M., Nilsen, T. RNA: Versatility in form and function. Nat Struct Mol Biol 7, 831–833 (2000). https://doi.org/10.1038/82816
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DOI: https://doi.org/10.1038/82816
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