Volume 32 Issue 3, March 2022

The image describes a Chinese fairy tale, the “King Yu tamed the flood”, wherein King Yu recruited and directed people to mend the broken river wall. Pre-ribosomal RNA interacts with MDC1 and may direct repair factors, such as TopBP1 and BRCA1, to DNA double-strand breaks in the XY body of male germ cells as well as in somatic cells. See page 254-268 by Xiaochen Gai et al. for details.

Research Highlight

An exercise infusion benefits brain function

Alejandro Pinto
Henriette van Praag
Research Highlight 24 Jan 2022
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The hens guarding epithelial cancer fox-houses

Liam T. Gaynor
Ramesh A. Shivdasani
Research Highlight 29 Nov 2021
How to dodge pyroptosis: lessons from Shigella flexneri

Filip Van Hauwermeiren
Mohamed Lamkanfi
Research Highlight 22 Dec 2021
Muscularis macrophages: trained guardians of enteric neurons

Maria Francesca Viola
Guy Boeckxstaens
Research Highlight 13 Dec 2021

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Review Article

Mechanisms of Polycomb group protein function in cancer

Victoria Parreno
Anne-Marie Martinez
Giacomo Cavalli
Review Article Open Access 19 Jan 2022

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Article

Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response

Xiaochen Gai
Di Xin
Xiaochun Yu

Collection:

Editor’s selections: top articles from the past 3 years
Article 04 Jan 2022
A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

Zezhong Liu
Jie Zhou
Lu Lu

Collection:

Editor’s selections: top articles from the past 3 years
Article Open Access 19 Jan 2022
Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate

Ao Hu
Jing-Zan Zhang
Bao-Liang Song
Article 04 Feb 2022
Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis

Chao Dou
Zhaolin Long
Wei Cheng
Article Open Access 02 Feb 2022

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Letter to the Editor

Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2

Shuyuan Zhang
Qingtai Liang
Xinquan Wang
Letter to the Editor Open Access 12 Jan 2022
Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates

Denisa Bojkova
Marek Widera
Jindrich Cinatl Jr
Letter to the Editor 21 Jan 2022
SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination

Pengfei Li
Yining Wang
Qiuwei Pan
Letter to the Editor Open Access 20 Jan 2022

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Volume 32 Issue 3, March 2022

Research Highlight

An exercise infusion benefits brain function

The hens guarding epithelial cancer fox-houses

How to dodge pyroptosis: lessons from Shigella flexneri

Muscularis macrophages: trained guardians of enteric neurons

Review Article

Mechanisms of Polycomb group protein function in cancer

Article

Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate

Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis

Letter to the Editor

Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2

Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates

SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination

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