Volume 31

  • No. 5 May 2021

    The cover depicts a newly built elevated highway (replicating DNA) that is damaged (mismatch). A worker (MutS-MutL complex) identifies the damage and communicates with the repair department (Exo1) to fix the problem. The columns (buildings) represent chromatin remodeling and DNA metabolic proteins. Designed by Yipin Wu.See page 542-553 by Janice Ortega et al. for details.

  • No. 4 April 2021

    Paired Chinese knot, a symbol of unity and cooperation, represents the active state structure of human calcium-sensing receptor (CaSR), a dimeric class C GPCR responsible for maintaining Ca2+ homeostasis in the blood. Structural studies revealed that CaSR is cooperatively activated by calcium ions and L-Trp. See page 383-394 by Shenglong Ling et al. for details.

  • No. 3 March 2021

    Buddha or evil, depends on a blinding flash. Neddylation can switch PTEN from a tumor suppressor (Buddha) to a tumor promoter (evil). See page 291-311 by Ping Xie et al. for details.

  • No. 2 February 2021

    Formation of ER whorls by COPII machinery is a new type of UPR response. See page 141-156 by Fang Xu et al. for details.

  • No. 1 January 2021

    Ca2+-induced (fallen leaves) and phosphatase-checked (shrimps) shuttling of CaMKII (lotuses) enlarges postsynaptic density assembly (larger cluster of fish) and induces structural long-term potentiation.