Letter to the Editor in 2021

Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139

• Yali Zhou
• Henrik Daver
• Zhi-Jie Liu

Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine

• Yunlong Cao
• Xiaohua Hao
• Ronghua Jin

Spontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development

• Xinxin Zhu
• Na Yang
• Huayi Wang

Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

• Yuanchao Xie
• Wanchao Yin
• Jingshan Shen

Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3–Gi signaling complexes

• Chang Zhao
• Lin Cheng
• Zhenhua Shao

The ChinaMAP reference panel for the accurate genotype imputation in Chinese populations

• Lin Li
• Peide Huang
• Weiqing Wang

Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants

• Hua Xu
• Bo Wang
• Xiao-Dong Su

Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants

• Shuo Du
• Pulan Liu
• Junyu Xiao

Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently

• Zimo Yang
• Yonghui Sun
• Yu Rao

Time of day influences immune response to an inactivated vaccine against SARS-CoV-2

• Hui Zhang
• Yihao Liu
• Haipeng Xiao

O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule

• Wenmin Tian
• Delin Li
• George Fu Gao

SDX on the X chromosome is required for male sex determination

• Junfeng Zhan
• Peng Cui
• Mengcheng Luo

Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT_1F–G protein complex

• Sijie Huang
• Peiyu Xu
• H. Eric Xu

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G_s

• Lu Xu
• Bo Chen
• Fei Xu

Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

• Jinge Gu
• Chen Wang
• Cong Liu

Enhancing prime editing by Csy4-mediated processing of pegRNA

• Yao Liu
• Guang Yang
• Xiaolong Wang

Nuclear translocation of the 4-pass transmembrane protein Tspan8

• Yuwei Huang
• Junjian Li
• Hongxia Wang

A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau

• Dongming Xu
• Cuiping Yang
• Peng Shi

Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin

• Yao Zhou
• Diyin Li
• Liang Tao

Structural basis of human α7 nicotinic acetylcholine receptor activation

• Yue Zhao
• Sanling Liu
• Changlin Tian