One-pot synthesis of cyclodextrin-based radial poly[n]catenanes

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    Oligomerisation is widely used to engineer proteins and peptides with desirable properties. Here, covalent homodimers and heterodimers of fluorescent proteins are designed in silico and experimentally shown to exhibit differing spectral properties depending upon the structure of the protein-protein interface.

    • Harley L. Worthy
    • , Husam Sabah Auhim
    • , W. David Jamieson
    • , Jacob R. Pope
    • , Aaron Wall
    • , Robert Batchelor
    • , Rachel L. Johnson
    • , Daniel W. Watkins
    • , Pierre Rizkallah
    • , Oliver K. Castell
    •  & D. Dafydd Jones
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    Magnesium-sodium dual-ion batteries are promising for energy storage but their utility is limited by low oxidative stability of dual-ion electrolytes. Here, the authors demonstrate an oxidatively stable sodium-ion electrolyte and a sodium-ion conductive β-alumina membrane on the cathode side of the battery.

    • Kostiantyn V. Kravchyk
    • , Marc Walter
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    The merger of chemical and biocatalysis can offer powerful new options to synthetic chemists. Here a combination of a nickel-catalyzed Suzuki-Miyaura reaction and an enzymatic stereoselective reduction provides enantiomerically-enriched alcohols from amides in a single reaction vessel, in water.

    • Jacob E. Dander
    • , Maude Giroud
    • , Sophie Racine
    • , Evan R. Darzi
    • , Oscar Alvizo
    • , David Entwistle
    •  & Neil K. Garg
  • Article | | open

    Oxidised copper complexes are important bioinorganic intermediates, and many typically react as electrophiles. Here a copper(II) hydroperoxo complex is shown to be nucleophilic towards acyl chlorides and aldehydes

    • Bohee Kim
    • , Donghyun Jeong
    • , Takehiro Ohta
    •  & Jaeheung Cho
  • Article | | open

    MitoNEET is an iron-sulfur protein found in the outer mitochondrial membrane and implicated in several metabolic disorders. Here the crystal structure of mitoNEET with a bound sulfonamide ligand is reported and used to design new mitoNEET ligands.

    • Werner J. Geldenhuys
    • , Timothy E. Long
    • , Pushkar Saralkar
    • , Toshio Iwasaki
    • , Raisa A. A. Nuñez
    • , Rajesh R. Nair
    • , Mary E. Konkle
    • , Michael A. Menze
    • , Mark V. Pinti
    • , John M. Hollander
    • , Lori A. Hazlehurst
    •  & Aaron R. Robart
  • Article | | open

    There are several structural motifs commonly reported for polycatenanes although radial polycatenanes remain poorly studied. Here, the authors report the facile synthesis of cyclodextrin based radial polycatenanes composed of more than ten rings via a polypseudorotaxane intermediate.

    • Taishi Higashi
    • , Kentaro Morita
    • , Xia Song
    • , Jingling Zhu
    • , Atsushi Tamura
    • , Nobuhiko Yui
    • , Keiichi Motoyama
    • , Hidetoshi Arima
    •  & Jun Li
  • Article | | open

    The efficient biocatalytic processing of cellulose is a longstanding goal. Here, an ancient endogluconase is recreated using ancestral sequence reconstruction and the basis for its thermal stability and favourable catalytic properties are probed computationally.

    • Nerea Barruetabeña
    • , Borja Alonso-Lerma
    • , Albert Galera-Prat
    • , Nadeem Joudeh
    • , Leire Barandiaran
    • , Leire Aldazabal
    • , Maria Arbulu
    • , Miguel Alcalde
    • , David De Sancho
    • , Jose A. Gavira
    • , Mariano Carrion-Vazquez
    •  & Raul Perez-Jimenez
  • Article | | open

    The decomposition of sulfuric acid molecule in the stratosphere contributes to the depletion of ozone layer and therefore requires improved understanding. Here the authors present a theoretical approach to understand the sulfuric acid loss mechanism of potential atmospheric significance.

    • Montu K. Hazra
    • , Sourav Ghoshal
    • , Prabhash Mahata
    •  & Biswajit Maiti

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