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Sarcomeres of Ca2 + -activated demembranated fibres of rabbit soleus muscles show that the stress exerted by each motor protein on the thin filament determines the cooperativity in thin filament activation.
A tree-based adaptation of a hidden Markov model captures heterogeneity and cell state transitions based on single-cell lineages, enabling the study of intrinsic or drug-induced plasticity in heterogeneous cell populations.
The bacterial/archaeal and fungal communities inhabiting beech tree root-tips are examined by marker gene sequencing followed by ecological network analysis, highlighting complex interactions in the ectomycorrhizal symbiosis.
Crystal structures of integrin β5 tails with PAK4 reveal a unique interaction in which integrin β5 is not phosphorylated by PAK4 but rather inhibits PAK4 activity.
The efficacy and toxicity of the PARP inhibitor parthanatine, radiolabeled with the alpha particle emitter astatine-211, in 11 patient derived neuroblastoma murine xenografts is investigated.
A C. elegans model of Duchenne muscular dystrophy reveals a potential role for disrupted sulfur metabolism in the disease and thus the therapeutic potential of sulfur amino acid supplementation.
Simulated data and experimental muscle activity data from stepping neonates, infants, pre-schoolers, and adults, shows that complexity of modularity increases with age and that low complexity and high variability of neuromuscular signals characterises neonatal immaturity.
Activity-based protein profiling is used to screen lignocellulose-degrading enzymes from the white rot fungus Phanerochaete chrysosporium to identify those specifically active in the presence of wood substrate.
A microscopy-based screen of Medicines for Malaria Venture Pathogen Box identifies Trifloxystrobin as an effective alternative to Buparvaquone treatment for Theileria parasites infection, by inhibiting parasite survival and differentiation.
The structure and function of two isoflavone biosynthetic enzymes are reported revealing a novel cytochrome P450 conformation and identification of key residues for dual dehydratase and carboxylesterase activities
Mitochondrial disruption in the red flour beetle leads to insects with three layers of cuticles (larval, pupal, and adult) and blocks the wing development.
Nuclear magnetic resonance spectroscopy-based tissue metabolomics is used to define detailed temporal signatures of acute and chronic inflammation in cutaneous delayed-type hypersensitivity reaction.
The guanine exchange factor DOCK2 regulates the development of immunomodulatory function in human stromal cells (mesenchymal stem/progenitor cells (MSPC) and fibroblasts), as demonstrated in three models.
Quantitative global phosphotyrosine proteomics of two mouse models of hypertrophic cardiomyopathy reveals that tyrosine kinase inhibitors may be a future therapeutic approach for treating hypertrophic cardiomyopathy.
A peptide that specifically targets amino acid transporter SLC1A5 in colorectal cancer cells is identified and conjugated with camptothecin to show selective cytotoxicity to colorectal cancer cells in preclinical models.
An EEG, fMRI, and behavioural investigation of five object dimensions related to animacy provides insights into how distinct dimensions (and animacy) are represented in the brain and behaviour.
A computational modelling framework is developed, and used to reconstruct and simulate the entire cerebellar cortex, showing how mossy fibers entrain the neuronal microcircuit. This sheds light on local computation and neural correlates of behaviors
Further evidence for an explosive marine reptile diversification event in the Early Triassic is presented via morphological analysis of a new Sclerocormus specimen.