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The interplay of mesenchymal and endothelial cells with breast cancer (BC) cells are investigated in a synthetic tumor microenvironment mimics (STEM) and CAM model to assess migration and metastasis.
A pseudotime analysis of the host cell response to SARS-CoV-2 infection using publicly available scRNA-seq data derived from in vitro studies reveals a non-lineal, triphasic transcriptional response and suggests a global regulatory mechanism.
The genetic alterations, protein expressions, and clinical characteristics of growth hormone-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors are integrated to detect molecules associated with acromegaly characteristics.
Multimodal single-cell analysis on iPSC-derived kidney organoids shows that inhibiting EZH2 attenuates TGFβ1-induced fibrotic gene expression and changes in chromatin accessibility, highlighting a potential therapeutic strategy for renal fibrosis.
Members of the conserved TOG/XMAP215 family possess microtubule polymerase activities; however, Dis1 in fission yeast is shown to promote microtubule catastrophe.
Selective DREADD-mediated activation of the lateral septum reveals its importance in enabling male prairie voles to adjust selective and nonselective social behavior to account for important life-history shifts linked with reproductive success.
A Neisseria cinerea Cas9 variant is characterised in PAM preference, editing efficiency (for both nuclease and base editing) and anti-CRISPR protein blocking, with a PAM of (N)4GYAT reported alongside a mouse zygote assay.
Multivariate brain-behaviour associations are studied with regularized canonical correlation analysis and a machine learning framework, showing that behavioural inter-individual variability is linked to inter-individual variability in brain structure.
A draft genome assembly of Cremastra appendiculata (D. Don) Makino, a traditional Chinese medicine plant, identified genes responsible for plant colchicine biosynthesis.
SET8 is post-translationally poly ADPribosylated by PARP1 on several lysine residues, leading to SET8 degradation via ubiquitylation and genome-wide aberrant H4K20 methylation.
Cryo-EM structures reveal the role of glutathione (GSH) in poliovirus (PV) serotype 3 virus-like particle (VLP) stability, suggesting GSH or an analogous tight-binding antiviral offers potential for stabilizing VLP vaccines against PV.
The three RH-RhoGEFs differ in their sensitivity of activation by G proteins. For p115-RhoGEF, a specific molecular interaction with Gα13 is responsible for faster kinetics and lower sensitivity.
Vitamin D has an impact on mitochondrial biogenesis and oxidative activity in skeletal muscle both in vitro and in vivo, and vitamin D supplementation in older people may improve muscle mass and strength.
A nucleoside degradation pathway in halophilic archaea is identified, which converts the ribose moiety of guanosine to dihydroxyacetone phosphate and ethylene glycol.
Wolf behavioural, spatial, and serological data over 26 years show that wolf territory overlap with areas of high cougar density is a significant predictor of T. gondii infection. Further, infection increases the likelihood that wolves make high-risk decisions such as dispersing and becoming a pack leader.
Insights are provided into the action of gp7, a small protein encoded by the bacteriophage GIL01 in the biopesticide Bacillus thuringiensis serovar israelensis. Gp7 1 hinders the induction of cohabiting prophage pBtic235 and downregulates its genes in a complex with host LexA in stressed cells.
DrugnomeAI predicts the druggability likelihood for every protein-coding gene in the human exome by small molecules, monoclonal antibodies, and proteolysis-targeting chimeras (PROTACs).