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TLR5 agonists in combination with immune checkpoint therapies (ICT) enhance survival in ICT-refractory murine 4T1 mammary carcinoma and B16-F10 melanoma tumors. Low serum levels of G-CSF and CXCL5 correlate with enhanced survival.
Long-term intermediate fasting before pregnancy in mice disrupts intestinal homeostasis of offspring with subsequent glucose and lipid metabolism disorder, mediated by a reduction in beneficial microbiota such as Lactobacillus intestinalis.
A TGFβ/BMP receptor library with Halo- and SNAP-tags is generated and with the application of labeled growth factor ligands, a ligand surface binding assay is developed, allowing assessment of preferential ligand-receptor binding in cells.
A meta-analysis of 17 cohorts of mitochondrial disease patients reveals that OxPhos defects are associated with signs of hypermetabolism. Experiments in patient-derived fibroblast show that mitochondrial OxPhos defects trigger hypermetabolism in a cell-autonomous manner and this is linked to accelerated telomere shortening and epigenetic aging.
Genome assembles for Northern three-toed jerboa, Siberian jerboa, Midday jird and Desert hamster and provides insights into similarities and differences in mechanisms for desert adaptation.
ZNF185 is identified as a novel PKA substrate and found to be important for the organization of endothelial cell–cell junctions and suppression of vascular hyperpermeability by regulating the cAMP/PKA/RhoA signaling pathway.
Cryo-EM structures of E. coli F1Fo ATP synthase highlight the role of the inhibitory ε subunit in regulating the torsional movement of the central stalk within the Fo motor and central stalk flexibility in coupling the F1 and Fo motors.
Spatiotemporal application of two biocontrol strains, Piriformospore indica and Streptomyces morookaensis, inhibits the soil-borne fungus Foc TR4 growth and reduces Fusarium wilt of banana.
A metagenomic analysis reveals that male and female mice exhibit sex-dependent responses to a high-fat diet (HFD), and that estrogenic ligands can attenuate certain aspects of HFDinduced dysbiosis.
Comparative phenotyping and genome-wide association study in a panel of 149 wheat genotypes reveal alleles associated with heat tolerance, which could be useful in future breeding programmes for wheat cultivars.
In transgenic mice, early-life exercise is shown to potentially impact neuronal epigenetic regulation and gene expression during hippocampal memory consolidation.
Highly concentrated trehalose induces beneficial senescence-like state in fibroblasts and accelerates the proliferation of keratinocytes and angiogenesis to promote optimal wound repair, demonstrating its therapeutic potential in modulating fibroblast functions.
Phylogenetic analyses demonstrate a remarkable variety of the degenerin/epithelial Na+ channel (DEG/ENaC) superfamily in Cnidaria and discern an unexpected role for a proton-sensitive DEG/ENaC in N. vectensis cnidocyte discharge.
Magnetoencephalography recordings from participants in a visual detection task reveals that sounds improved visual detection sensitivity by enhancing the accumulation and maintenance of perceptual evidence over time.
A bidirectional interaction between Pseudomonas aeruginosa (PA) bacteria and cancerous tumors results in an anti-tumor effect; cancer cells stimulate PA-secretion of azurin which promotes tumor cell production of aldolase A.
The subunit composition of GABAA receptors and their interaction with beta spectrin complexes influences their localization between the neuronal axon initial segment or dendrites.
Chemogenetic and optogenetic profiling in a rat model of acute pain-related unpleasantness suggests that colorectal distention-induced place aversion is mediated by locus coeruleus noradrenergic signalling to astrocytes in anterior cingulate cortex.