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Structural and mutagenic analyses reveal the mechanistic basis of azurin-mediated p53 stabilization and tumor suppression, and several affinity-enhancing azurin mutants are designed.
Single Molecule Imaging Simulator (SMIS) simulates how the photophysical behavior of fluorophores in single-molecule localization experiments influences experimental data, as evidenced by applying SMIS to several imaging scenarios.
Structures of Methanosarcina barkeri trimethylamine methyltransferase (MttB) with its substrates reveal the role of pyrrolysine in methyl group transfer from trimethylamine to the corrinoid cofactor in MttC.
Dihydroartemisinin (DHA) promotes Treg cell proliferation and suppresses plasma cell expansion through direct interaction and activation of c-Fos, underling the bilateral immunoregulatory mechanism of DHA.
The spatial organization and intracellular dynamics of the stressosome proteins in L. monocytogenesare revealed using photo-activated localization microscopy combined with single-particle tracking and single-molecule displacement mapping.
A genome-wide association study using summary statistics from the UK Biobank identifies ancestry-specific variants associated with pulmonary function among European and African ancestry cohorts.
rs-fMRI is used to investigate human brain connectivity changes induced by prolonged microgravity in cosmonauts before and after spaceflight, with both persistent and reversible location specific changes in connectivity being observed.
Mechanical compression drives activated muscle stem cells (MuSCs) into a quiescent stem cell state providing insight into MuSC activity during injury-regeneration cycles.
A comprehensive optimization of phenotypic and computational screening strategy for antifilarial drug and target discovery identifies compounds with stage, species, and/or sex-specific activity, some with submicromolar potency.
Global tree abundance is demonstrated to correlate with latitudinal variables, with tree size and self-thinning strategies impacting current estimates of tree count.
The cryo-EM structure of monoclonal antibody aE11 bound to polyC9 reveals that the binding site within the Membrane Attack Complex is a quaternary discontinuous epitope formed by two separate surfaces of the oligomeric C9 periphery.
A longitudinal characterization of the gut microbiome in 30 pediatric hematopoietic stem cell transplantation patients reveals that the combination of levofloxacin prophylaxis and parental nutrition disrupts gut microbiome networks.
Functional and transcriptomic comparison of primary neonatal, adult and ESC-derived astrocytes reveals major variations, highlighting the importance for an informed choice of astrocyte origin for research questions.
Comparative site-specific N-glycoproteome analysis of tumorigenic and non-tumorigenic colon cancer cells provides a pool of potential N-glycosylation related cancer biomarkers and insights into the mannose-6-phosphate pathway in cancer.
Polyehylene terephthalate (PET) biodegradation is greatly improved when recombinant IsPETase is expressed in Pichia pastoris and the enzyme’s partial removal of N-terminal glycosylation, retaining high thermostability.
TLR5 agonists in combination with immune checkpoint therapies (ICT) enhance survival in ICT-refractory murine 4T1 mammary carcinoma and B16-F10 melanoma tumors. Low serum levels of G-CSF and CXCL5 correlate with enhanced survival.