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A hair-thin fibre-optic imaging system that can image the mechanical properties of single-cellular and multi-cellular organisms in 3D with sufficient resolution to identify 300 nm structures in the C. elegans cuticle.
Characterization of nuclear and nucleolar dynamics during adipogenic differentiation of human adipose stem cells points to nucleolar remodeling as an active, mechanoregulated mechanism triggered by cytoskeleton rearrangement.
This study investigates interspecies interaction in a synthetic co-culture consisting of the sucrose-secreting cyanobacterium S. elongatus cscB and its sucrose-consuming partner P. putida cscRABY by employing a comprehensive multi-OMICs approach.
Theory predicts that bacteria living under pulsed growth regimes adapt to pulse duration by adopting different strategies ranging from nimble to torpid responders. Physiological responses to pulse duration of soil bacteria fit the predictions.
Epidermal retinol dehydrogenases 2 (SDR16C5) and RDHE2-similar (SDR16C6) are the major retinol dehydrogenases in skin, which regulate hair cycling, hair composition, hair follicle stem cell markers, and circadian clock genes.
In graft rejection, Th17 promotes tertiary lymphoid tissue, neutrophilic infiltration and DSAs. The RORγt inverse agonist TF-S14 inhibits Th17 cytokines, antibody class switching and prolongs allograft survival in sensitized mice.
A study on the palatal region of pterosaurs suggests different bone interpretations and new identification of the palatal openings, pointing out that the maxillopalatine fenestra in pterosaurs is unique within Diapsida.
Glutamate production from aerial nitrogen was achieved at 1 g L−1 by nitrogen-fixing bacteria, expecting aerial nitrogen utilization for future sustainable bioproduction of N-containing compounds.
A proteome-scale analysis of human coding variants reveals constrained sites in thousands of domains. This highlights key structural or functional residues, including pathogenic sites, especially when integrated with evolutionary conservation.
A novel phylum of bacteria widespread in oligotrophic marine sediments are capable of oxidizing nitrite to nitrate and could resolve the apparent abundance mismatch between ammonia- and nitrite-oxidizers.
A study focused on the Ross Sea found that sinking of Antarctic silverfish eggs and faeces promotes the biological carbon pump contributing to a large amount of the annual carbon export.
This study highlights the essential role of zyxin for podocytes. Zyxin loss in vitro reduced the expression of vinculin, VASP and matrix proteins. In mice, the knockout of zyxin resulted in proteinuria and effacement of podocyte foot processes.
A unique soluble β-carotene-binding protein pigment extracted from yellow locust cuticle is biochemically and spectroscopically equivalent to the protein reconstituted in carotenoid-producing E. coli cells and capable of binding to chitin in vitro.
In Zebrafish embryos spinal cords, neural precursors are clustered in two distinct populations based on their spindle-microtubule enrichment. KIF16Ba, CAMSAP2a/3a and spindle-microtubule enrichment control Sara endosome motility and mediate neural precursor fates.
Generation of an endogenous Cyp1a1 luciferase reporter mouse model to dynamically and longitudinally visualize AHR activity throughout lifespan and in response to ligand exposure, reveals prolonged AHR activation in the lung.
A genetic study that explores the relationship between risk behaviours engagement in adolescents and educational achievement. This study found that risk behaviours were phenotypically associated with educational achievement at age 16, even after adjusting for confounders.
Finite element analysis shows distinctive strengthened cranial biomechanics in Oviraptorosauria compared with other herbivorous theropod dinosaurs, established prior to the highly modified oviraptorid cranial morphology.
Multiscale molecular dynamics simulations reveal rapidly exchanging lipid binding sites on the nicotinic acetylcholine receptor, including sites with high affinity for phosphatidic acid and promiscuous cholesterol sites in inter-α-helix grooves.