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The feather-degrading bacterium Bacillus licheniformis MW3 contains a sulfur-metabolizing gene cluster, in which one sulfide-sensor and one sulfane sulfur-sensor synergistically control gene expression, enabling the bacterium to grow on bird feathers.
Combined PET imaging and mathematical simulations reveal that the rate of dopamine increase in the striatum underlies self-reports of drug “high” in response to oral and intravenous methylphenidate challenges in humans
The role of the transcription factor Fosl-2 in promoting myocardial fibrosis, arrhythmias and aberrant response to stress under immunofibrotic conditions is described using an in vivo mouse model and human cardiac fibroblasts.
A new protein domain classification protocol incorporating deep learning strategies for detecting sequence and structure similarities between domain is used to systematically study and analyse the predicted AlphaFold2 structural models for proteins of 21 organisms.
Survival in extreme environments and adaptations during seasonal shifts require specialized metabolic programing. A multi-omic analysis of how regulatory networks impact adipose homeostasis in sheep tails provides insight for how these animals survive extreme environments.
The use of single-molecule optical tweezers shows that complexin-1 shapes the assembly of the Synaptic-soluble N-ethylmaleimide-sensitive factor Attachment Receptor by multiple domains’ coordination.
A multi-omic analysis of 11 Mycobacterium tuberculosis (Mtb) isolates with different drug resistance profiles leads to the discovery of Rv3094c, an enzyme capable of activating the clinically relevant Mtb drug, ethionamide.
Genome-wide analyses of admixture between two closely related and sympatric North American oriole species reveals longstanding barriers enforcing reproductive isolation.
Physiological experiments in Heterosigma akashiwo provide metabolic insights to the future of algal blooms under warming and acidifying ocean conditions.
The genetic structure of modern-day brown bears mainly reflects contemporary population connectivity. Recent gene flow barriers have obscured the genomic signatures of postglacial recolonisation.
Population genomic analyses and palaeogeographical modelling combine to help infer the ancient migration of humans into South Asia from Sundaland, driven by rapid sea level rises.
In a breast cancer cell line migrating through microchannels, stress-responsive paraspeckle numbers increase under confinement and polarize towards the leading edge.
A new method, named array fluorescent micro-optical sectioning tomography (array-fMOST), is developed for identifying the three-dimensional information at single-cell resolution from multi-samples.
Multivariate neuroimaging analyses of participants in a texture discrimination task suggests that cognitive fatigue via repeated stimulus exposure impacts the activity of task-relevant networks and is associated with tangible behavioral repercussions.
Analyses of colouration, head shape, and genetic markers across pairs of neighbouring beach and inland habitats reveal replicated patterns of morphological divergence in the Madeiran wall lizard, despite gene flow between habitats.
Molecular dynamics simulations of multidrug resistance protein 1 (MRP1) with varying membrane composition suggest that the composition has limited impact on the structures, but rather affects the conformational transitions and kinetics of substrate transport.
The role of mammary gland tissue-resident macrophages (MGTRMs) in the development of TNBC breast tumors and recurrence after surgery and chemotherapy is investigated.