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A proof-of-concept study on the genomic evolution of SARS-CoV-2 during antiviral treatment reveals that Molnupiravir induces a higher in vivo intra-host variability compared to Paxlovid and drug-naive.
A multi-year stress experiment with broadcast spawning coral reveals that colonies exposed to a marine heatwave shift their reproductive strategy towards smaller but more numerous eggs, which, together with physiological acclimation, confers resilience to subsequent thermal stress.
Single-cell RNA sequencing of early to mature adult Drosophila eyes reveals new cell type-specific marker genes and a full set of transcriptomic data for this tissue.
CryoEM structures and computational modeling of bovine anion exchanger 1 in both inward and outward facing conformations reveal an elevator-like mechanism of ion transport by a solute carrier ion transport family 4 member.
The DNA origami design algorithm DAEDALUS is modified to design a nanoscale cube with a two-step assembly protocol, assembling 9 modules from three DNA scaffolds and the complementary staples, combined to form the DNA origami cube.
Transcriptomic and proteomic analyses reveal that glycosylation and carbohydrate metabolism are central processes in heart regeneration in zebrafish, including a shift from OXPHOS to glycolysis seven days after injury.
The software tools and user interfaces for the registration and exploration of tissue data for the human reference atlas are presented, providing evaluation metrics for data quality examination and guidance for data acquisition in support of reference atlas construction.
A genome-wide analysis in galloping racehorse breeds identifies protein-altering genetic variants in a core set of genes that appear to determine attributes for racing, including muscle, neurobiological, and metabolic advantages.
The extinction debt being paid in modern biodiversity crashes began in the Second Industrial Revolution, indicating a long-term anthropogenic impact on forest species richness.
Using a support vector machine learning approach and multi-omics data, dysregulation of key cancer driver pathways is revealed in cancer cell lines compared to primary tumors.
Cpt1a-dependent fatty acid beta-oxidation is found to regulate neutrophil trafficking to the site of infection in a mouse model of pneumonia and is found to play a role in pneumonia susceptibility in humans.
L1CAM is implicated as an important factor that enables early fallopian tube cancer precursors to seed the ovary by promoting cell survival through extracellular matrix signaling, thereby facilitating ovarian cancer growth.
Real-time imaging of fungal infection and tissue clearing in the wax moth, Galleria mellonella, help evaluate the role of melanin in the insect host immune response to fungal pathogens.
Pseudomonas putida has been engineered to produce medium chain length oleochemicals, including medium chain length free fatty acids and their ester forms, compounds which may be useful as biodiesel blending agents.
Resting state oscillatory activity is shown to predict visual exploration phenotypes, with reported correlations between resting state and eye movement dynamics recorded one year before.
The effect of trimodal visuo-audio-tactile stimulations on perceptual realism during vehicle riding simulations in virtual reality reveals that multisensory plausibility engages cortical activities in the frontal-parietal and sensorimotor regions.
A magnetic nanoporous membrane is engineered for immunocapture of extracellular vesicles and lipoproteins in heterogeneous physiological fluids, such as plasma and saliva, and quantification of cargo and biomarkers in these nanocarriers.
Salt-induced promoters are identified in Vibrio natriegens and used to engineer a strain for potential application in degradation of microplastics in marine water.