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A nutritive hydrogel enhances the survival of human mesenchymal stromal cells by providing physiological glucose levels in a controlled manner, eliciting new blood vessel formation in vivo.
scPML is a pathway-based multi-view learning model that outperforms alternative approaches in cell type annotation and detecting unknown cell types across diverse species, platforms, and tissues.
An updated, chromosome-scale genome assembly of quinoa enables the characterization of subgenome dynamics, including the identification of large structural rearrangements. The B subgenome is also more dynamic and has expanded more than the A subgenome.
The study shows, by comparing CoV2 vs flu infection, that CoV2 infection fails to induce of Krt5+ “pod” formation and cell proliferation and mediates more profound chronic effects on the lungs including fibrotic abnormalities than flu infection.
In vivo recordings show that a subset of supramammillary neurons that project to the medial septum are wake-active, and projection-specific manipulations reveal that this hypothalamic-septal projection contributes to wakefulness modulation.
Joint connectomic and transcriptomic analyses of longitudinal dMRI data reveal the multiscale developmental pattern of the human white matter connectome from childhood to adolescence.
Short-term tracking of treefrogs in southern Brazil, alongside microbiome and stress hormone profiling, suggests that forest fragmentation impacts microbiome diversity and composition, and that these changes might be mediated by the host stress response.
A super-resolution light-field imaging method enables video-rate 3D imaging of intracellular dynamics beyond diffraction limit and with strong noise-resistant capability.
New palaeodictyopteran larvae show similar form and surface microstructures on lateral abdominal outgrowths and thoracic wing pads, suggesting that paired serial outgrowths on segments of both tagmata functioned as ancestral type of gills, resembling a protopterygote model.
Network-based restoration strategies that prioritize the reintroduction of highly connected species maximize the recovery of biodiversity following ecosystem collapse.
An NMR study on K113-ubiquitinated BAK complex reveals that the conjugated ubiquitin subunit binds to the canonical hydrophobic groove of BAK, which prevents the binding of prodeath BH3 activators and impairs BH3-induced BAK apoptotic activity.
Super-resolution imaging and RNA clock analyses show that exposure of mouse oocytes to ionizing radiation compromises chromatin organization and dramatically accelerates biological aging.
This manuscript investigates the binding mode of a potent SARS-CoV-2 neutralizing antibody. N3-1 is escaped by Omicron variants due to altered spike dynamics. This work suggests the need for innovative vaccine designs to combat evolving variants.
This study reveals that ATG7, beyond its established role in autophagy, interacts with PDCD4 and AKT1 to regulate translation during metabolic stress. The ATG7PDCD4 axis operates as a metabolic adaptation pathway, conserving energy and fostering cell survival under stress.
The progranulin-derived synthetic protein Atsttrin affects osteoclastogenesis and osteoblastogenesis via the TNFR signaling pathway, suggesting that this protein could potentially be used to treat inflammation-related bone diseases like osteoporosis.
A genome-wide study suggests that the response of the pituitary gland to thyroid hormone is regulated by receptor-enhancer complexes that adjust dynamically to hypothyroid and hyperthyroid conditions.
An insect assemblage gathered from the Chorrillo Formation in Argentina constitutes an important set of insect body fossils for the Maastrichtian interval in the Southern Hemisphere.
Comprehensive characterization of the glucose-6-phosphate dehydrogenase (G6PD) Meyer variant that contains an R219G substitution suggests compromised dimerization, stability, and catalytic activity of the mutant enzyme causes chronic hemolysis.