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Single-cell transcriptomic characterization of intraocular and extraocular retinoblastoma suggests that SOX4 may drive the local extension of retinoblastoma.
High-resolution morphological reconstructions and computational models of cerebellar Purkinje cells (PCs) from humans and mice suggest that, while PCs in both species maintain similar spike discharge properties, human PCs developed more complex dendrites.
Development of MRM-MS assays for 2118 proteins in 20 mouse tissues enables accurate quantitation. Protein concentrations measured from 3 mouse strains using these assays demonstrate proteomic phenotyping and are provided in an online database.
A combination of pharmacological modulation with in vivo electrophysiology, 2-photon calcium imaging and behavioural analysis characterises the role of cholinergic M1 receptors in sensory information processing and perception.
Genomic, cellular, and biochemical analyses reveal that the homozygous p.R189W variant in TMOD1 leads to dysregulation of thin filament lengths in the heart and causes childhood-onset dilated and restrictive cardiomyopathy in three patients.
The pattern of coordinated rhythmic local field potential signals recorded from multiple social behavior-associated brain regions in mice conducting various social discrimination tasks reflects the social context of the subject mouse.
Elevated levels of alarmone guanosine tetraphosphate (ppGpp) in the cyanobacterium Synechococcus elongatus reduce de novo synthesis of 2-oxoglutarate, potentially by inhibiting metabolic enzymes like aconitase.
The cerebellum is more than just motor control: over the past 30 years, the notion that the “little brain” participates in cognitive functions and emotional response has grown to encompass social-related behaviors. Chao et al. bring to light the role of the cerebellar vermis in orchestrating a specific component of social memory in mice.
Defect in the death receptor signally caused by impaired FADD/BID expression leads to failure of T-cell mediated immunotherapy in multiple myeloma patients.
A study based on in vivo and in vitro experiments suggests that FTO enhances GnRH expression, which promotes puberty onset, by regulating m6A demethylation of PLCβ3 and activating the Ca2+ signalling pathway.
This study presents in vitro, in vivo, and human genetic evidence showing that the chromatin regulator SmarcAL1 plays an indispensable role in regulating cellular lipid metabolism, a mechanism linked to the lipid phenotypes seen in SIOD patients.
A set of functional genomics and statistical analyses identifies and establishes key determinants of transcriptional state dynamics and plasticity during tumor growth and under treatment in urothelial bladder carcinoma.