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A large-scale multi-cohort association study reveals strong and consistent impacts of birth order on DNA methylation events around the genome, potentially due to changes in placentation, nutrition, and growth factors between first and subsequent pregnancies.
To facilitate large-scale manufacturing of induced pluripotent stem cells, a Biological System-of-Systems (Bio-SoS) framework is proposed to model cell-to-cell interactions, spatial and metabolic heterogeneity, and cell response to micro-environmental variation.
In-silico based in vitro and in vivo validations identified a lead molecule that specifically targets: ApoE4 protein; inhibits ApoE4::CLEAR DNA binding; rescues thwarted lysosomal autophagy; and protects against Aβ aggregation.
A scRNA-seq study reveals a complex yet unique tumor microenvironment of laryngeal squamous cell carcinoma (LSCC) with lymphatic metastasis, and the data may help identify potential diagnostic biomarkers and therapeutic targets for LSCC.
Cryo-electron microscopy reveals the structure of a stacked overlapping tri-nucleosome assembly found downstream of transcription start sites of actively transcribed genes.
Mathematical and experimental approaches suggest that the organism may resort to autoimmunity to fine-tune erythrocyte lifespan as a strategy to adjust the number of cells circulating in the blood at any time.
This study investigates the ability to balance the energetic constraints of molting on land in a diving mammal, the southern elephant seal, the only phocid to experiment a catastrophic molt in a cold and windy environment.
A computational analysis of human kappa and lambda antibodies suggests that lambda antibodies are frequently less therapeutically developable due to their physicochemical properties, but that rational design strategies could reduce this risk.
Analysis of 7918 global carbapenem-resistant E. coli genomes reveals the transitions of diverse sequence types (STs), three host-switching events leading to the spread of resistance plasmids, and the crucial transmission country hubs and patterns of major STs.
High-quality genome assemblies, each generated using a single MinION flow cell, are reported for three critically endangered ash tree species, Fraxinus americana (white ash), F. nigra (black ash), and F. pennsylvanica (green ash).
A twin study reveals genetic effects on variability in major dimensions of aesthetic evaluations are shared across visual domains, whereas only environmental effects influence aesthetic tastes for abstract images.
The first X-ray crystal structure of a hetero-tetrameric septin complex is presented. From this a novel hydrophobic structural element conserved in septins from yeast to man is identified and characterized.
This study reveals that the proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2; these results provide a rational basis for the future development of idiopathic pulmonary fibrosis therapies.
New protocols allow the collection of fluorescence excitation and emission spectra from a variety of fluorescent plant megafossils, enabling research into the underlying fluorescent molecules, including potential remnants of original fluorescence.
STEM is a transfer-learning-based method that integrates spatial transcriptomics and scRNA-seq data to reconstruct localization at the single-cell level and reveal gene expression variation within cell types in tissues.
Mendelian randomization and colocalization analyses identified 13 circulating proteins causally associated with age at menarche and 7 proteins associated with age at natural menopause, highlighting the proteomic signatures encompassing both ends of women’s reproductive lifespans.
The σE regulon of Streptomyces coelicolor was determined in normal and ethanol treated conditions. Results of kinetic modeling, ChIP-seq and promoter mutagenesis suggested that σE can act both as a direct activator and repressor of transcription.
A multi-pronged activation approach applied to 54 actinobacterial strains doubles accessible metabolite space and enables discovery of gram-negative bioactivity, offering insights to harness nature’s chemical potential. The approach enhances or triggers natural product production across all 54 native actinobacterial strains, doubling total metabolite production and enabling the discovery of a new tetramic acid analog with gram-negative bioactivity. Insights from this large-scale study could lead to a more streamlined approach to unlock the full potential of nature’s chemical resources.