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Cytochrome P450 activity is assessed at the single-cell level using chemical imaging, Raman microscopy, which gives quantitative insights into effects of drug administration on cellular biochemistry.
Analysis of spatial, temporal, and frequency features through different datasets show that magnetoencephalogram data can be used to uniquely identify an individual among a group.
Combining a standard polygenic risk score (PRS) as a feature in a machine learning model increases the percentage variance explained for those traits, helping to account for non-linearities or interaction effects in genetics-based prediction models.
A transcriptome time course of Puccinia striiformis f. sp. tritici (Pst) infection reveals nuclear genes encoding chloroplast-localized proteins are manipulated during infection and highlights TaCSP41a disruption as a target for resistance breeding.
A phenome-wide genomic analysis on the UK Biobank cohort links >9,000 co-localized genes and >1,400 human phenotypes across a broad selection of human tissues, representing a useful resource for the investigation of relationships between gene expression, tissues, and human diseases.
Extracellular vesicles isolated from Salvia dominica hairy roots have a small round-shaped morphology and carry typical EV-associated proteins, and demonstrate pro-apoptotic activity in pancreatic and breast cancer cells
Real-time super-resolution microscopy analysis reveals the growth kinetics, morphology, and abundance of human insulin amyloid spherulites with different growth pathways.
Comparison of global gene expression patterns in con- and heterospecifically mated Drosophila mojavensis and Drosophila arizonae suggest that mating-responsive genes with divergent expression also exhibit more disrupted transcriptional profiles in heterospecifically mated females, providing further insight into the evolution of postmating-prezygotic reproductive isolation.
Joint scRNA-seq and proteomic analysis of the hypothalamus, cortex, and brainstem in mice provides insight into the cellular and molecular underpinnings of sleep homeostasis.
The spatiotemporal dynamics of the microglial inflammatory response to single vessel occlusion and recanalization are analysed, revealing four different response phases.
Analysis of real-time fMRI data from 59 participants undergoing neurofeedback training suggests that reinforcement learning contributes to successful self-regulation in the dopaminergic midbrain.
In an ecologically-relevant environment, rats respond differently to artificial fear conditioning compared to when a realistic threat, such as that of a predator, is introduced, which has implications for potential non-associative, rather than standard associative, fear processing.
An optimized method for mass spectrometry based immunopeptidomics analysis using high-field asymmetric waveform ion mobility spectrometry is presented and identifies 44,815 HLA-bound peptides (HLAp) from colorectal cancer samples.
Experiments on mice show that mental stress during early pregnancy can alter the functional status of endometrial receptivity and thereby pregnancy rates.