Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The adaptor protein Disabled 2 (Dab2) regulates the activation and self-renewal of hair follicle stem cells via canonical Wnt pathway. Importantly, Dab2 is also involved in the ageing process.
The epigenetic regulator, N(alpha)-acetyltransferase 40 (NAA40), induced by ecdysone, acetylates histone H4 and modulates ecdysone action in the regulation of insect metamorphosis.
This study shows that severity of disease in COVID-19 patients is characterized by the preferential loss of TCF1+ progenitor T-cells needed to self-renew and replenish the immune system.
The fastest growing bacterium known is Vibrio natriegens. We have fused the two chromosomes of V. natriegens to create a single chromosome strain. Our results show that the bipartite genome is not a prerequisite for its rapid growth
Brain shape and function are intricately related, and the morphological pattern of the right IntraParietal Sulcus appears significantly related to human memory and language performance.
“A transcriptome study of chicken primary myoblast proliferation and differentiation shows that the lncMDP1/miRNA-301a-5p/CHAC1 axis plays an important role in skeletal muscle development.“
An fMRI study on a navigation task in multidimensional abstract spaces showed that the human hippocampus, entorhinal cortex, and orbitofrontal cortex collaborate in learning abstract space structures.
Introducing GenomeNet-Architect, a neural architecture design framework that automatically optimises the overall layout of the architecture, the hyperparameters, and the training procedure of deep learning models for genome sequence data.
Proteomic study of mild hypothermia in skeletal muscle myoblasts from mice shows that hypothermia enhances mitochondrial metabolism and differentiation via the cold shock protein RBM3 and its overexpression even at room temperature can recapitulate these effects.
A study about the development of a quantitative agent-based model of yeast colony growth reproducing colony size measurements at various environmental conditions, like altered humidity, nutrient gradients, or varied initial colony inoculation.
Neoantigens derived from somatic mutations in KRAS represent promising targets for cancer immunotherapy. Through structure-based design, the authors identify the KRAS-G12V specific affinity-enhanced TCR, offering great promise for advancing cancer immunotherapy.
Snow avalanches—a direct physical process—represent a major source of mortality and comprise a previously undescribed pathway by which climate-linked mechanisms impact demographics of slow-growing populations of mountain-adapted animals.
Single molecule diffusion study to determine the impact of (poly)ribosome distribution, cell aging, protein aggregation, and biomolecular condensate formation on the spatial organization and mobility of proteins in bacteria.
A study on cryo-EM structural analysis of AFP, including N-glycosylation, fatty acids, and metal ion binding sites, and a systematic comparison with HSA.
A study using intracranial recordings in humans suggests that upcoming hand movements can be predicted by oscillatory brain features of the LFP signal.
A dominate modifier screen in Drosophila identifies transcriptional regulators that control expression of DIP-α, a cell surface protein, and synaptic target recognition in the neuromuscular system.
GWAS meta-analysis associates 12 sequence variants with essential tremor, identifies seven candidate causal genes including CA3 with multiomics-based analysis, and reveals key roles of dopaminergic and GABAergic neurons in the pathogenesis.